LOC108348139 Gene Summary [Rat]
HLA-DMB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DMA) and a beta (DMB) chain, both anchored in the membrane. It is located in intracellular vesicles. DM plays a central role in the peptide loading of MHC class II molecules by helping to release the CLIP (class II-associated invariant chain peptide) molecule from the peptide binding site. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | LOC108348139 |
| Official Name | class II histocompatibility antigen, M beta 1 chain [Source:RGD Symbol;Acc:11469141] |
| Ensembl ID | ENSRNOG00000051002 |
| Bio databases IDs | |
| Aliases | class II histocompatibility antigen, M beta 1 chain |
| Synonyms | D6S221E, DMb, H2-DMb2, H-2Mb2, histocompatibility 2, class II, locus Mb2, LOC108348139, major histocompatibility complex, class II, DM beta, major histocompatibility complex, class II, DM β, RING7, RT1 class II, locus DMb, RT1-DMb, RT1.DMb, RT1.Mb |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Loc108348139 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Immunoglobulin C1-set domain
- binding protein
- YXX-Phi motif
- immunoglobulin domain
- Immunoglobulin like
- Immunoglobulin I-set domain
- protein binding
- transmembrane receptor
- Class II histocompatibility antigen, beta domain
Pathways
Biological processes and signaling networks where the Loc108348139 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- schizophrenia
- laser induced choroidal neovascularization
- insulin-dependent diabetes mellitus
- septic shock
- dextran sodium sulfate-induced colitis
- COVID-19
- hypothyroidism
- androgenic alopecia
- lung squamous cell carcinoma
- squamous cell lung cancer
regulates
- CD74
- HLA-DMB
- HLA-DM
role in cell
- proliferation
- activation
- loss in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- intracellular membrane-bounded organelle
- cellular membrane
- lysosome
- MHC class II compartments
- lysosome membrane
- endosomal membrane
- late endosomes
- endocytotic vesicle
- multivesicular bodies
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Loc108348139 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of T cell activation
- peptide antigen assembly with MHC class II protein complex
- adaptive immune response
- positive regulation of T cell proliferation
- positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell
- antigen processing and presentation of exogenous peptide antigen via MHC class II
- positive regulation of immune response
- MHC class II protein complex assembly
Cellular Component
Where in the cell the gene product is active
- MHC class II protein complex
- late endosome membrane
- intracellular membrane-bounded organelle
- lysosomal membrane
Molecular Function
What the gene product does at the molecular level
- peptide antigen binding
- protein binding
- MHC class II protein complex binding