Extl3 Gene Summary [Rat]
Predicted to enable glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity; magnesium ion binding activity; and protein-hormone receptor activity. Involved in positive regulation of cell growth. Predicted to be located in endoplasmic reticulum. Predicted to be active in Golgi apparatus and plasma membrane. Orthologous to human EXTL3 (exostosin like glycosyltransferase 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Extl3 |
| Official Name | exostosin-like glycosyltransferase 3 [Source:RGD Symbol;Acc:62065] |
| Ensembl ID | ENSRNOG00000013581 |
| Bio databases IDs | |
| Aliases | exostosin-like glycosyltransferase 3 |
| Synonyms | 2900009G18Rik, AU040105, BOTV, exostosin-like glycosyltransferase 3, Ext1l, EXTL1L, EXTR1, ISDNA, LOC102549615, LOC105379344, LOC105379345, mKIAA0519, REGR, RPR |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Extl3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Exostosin family
- glucuronyl-galactosyl-proteoglycan
- ribitol-5-phosphate xylosyltransferase 1, and related proteins
- Glycosyl transferase family 64 domain
- acetylglucosaminyltransferase
- protein-hormone receptor
- enzyme
- protein binding
- glycosyltransferase
- magnesium ion binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- COVID-19
- immunoskeletal dysplasia with neurodevelopmental abnormalities
- myocardial infarction
- acute myeloid leukemia
- depressive disorder
role in cell
- differentiation
- generation in
- proliferation
- growth
- binding
- internalization by
- outgrowth in
- outgrowth
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cell surface
- Plasma Membrane
- Golgi Apparatus
- Endoplasmic Reticulum
- endoplasmic reticulum membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Extl3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of keratinocyte proliferation
- positive regulation of cell growth
- negative regulation of keratinocyte differentiation
- heparan sulfate proteoglycan biosynthetic process
- negative regulation of inflammatory response
- protein glycosylation
- positive regulation of detection of glucose
- negative regulation of cytokine production involved in inflammatory response
- positive regulation of protein kinase B signaling cascade
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- nucleus
- endoplasmic reticulum
- Golgi apparatus
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- magnesium ion binding
- transferase activity, transferring glycosyl groups
- protein binding
- glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity
- protein-hormone receptor activity