Prph Gene Summary [Rat]
Predicted to be a structural constituent of cytoskeleton. Involved in intermediate filament cytoskeleton organization. Located in neuronal cell body; terminal bouton; and type III intermediate filament. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis type 1. Orthologous to human PRPH (peripherin). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Prph |
| Official Name | peripherin [Source:RGD Symbol;Acc:3414] |
| Ensembl ID | ENSRNOG00000052880 |
| Bio databases IDs | |
| Aliases | peripherin |
| Synonyms | NEF4, Perf, PERIPHERIN, PRPH1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Prph often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Intermediate filament head (DNA binding) region
- binding protein
- coiled-coil domain
- protein binding
- Intermediate filament protein
Pathways
Biological processes and signaling networks where the Prph gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- susceptibility to amyotrophic lateral sclerosis
- amyotrophic lateral sclerosis 1
- motor dysfunction
- cognitive impairment
- astrocytosis
- microgliosis
- amyotrophic lateral sclerosis
- sporadic amyotrophic lateral sclerosis
- gait disturbance
- neurodegeneration
role in cell
- expression in
- apoptosis
- cell viability
- cell death
- formation
- outgrowth
- development
- organization
- phosphorylation
- maintenance
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- detergent-insoluble fractions
- Cytoplasm
- intermediate filaments
- cytosol
- nuclear envelope
- neurofilaments
- growth cone
- neurites
- photoreceptor outer segments
- perikaryon
- axons
- axon terminals
- detergent-soluble fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Prph gene, providing context for its role in the cell.
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- cytoplasm
- type III intermediate filament
- membrane
- intermediate filament
- perikaryon
- axon
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- structural molecule activity