SSR4 Gene Summary [Human]

This gene encodes the delta subunit of the translocon-associated protein complex which is involved in translocating proteins across the endoplasmic reticulum membrane. The encoded protein is located in the Xq28 region and is arranged in a compact head-to-head manner with the isocitrate dehydrogenase 3 (NAD+) gamma gene and both genes are driven by a CpG-embedded bidirectional promoter. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Mar 2011]

Details

Type
Protein Coding
Official Symbol
SSR4
Official Name
signal sequence receptor subunit 4 [Source:HGNC Symbol;Acc:HGNC:11326]
Ensembl ID
ENSG00000180879
Bio databases IDs NCBI: 6748 Ensembl: ENSG00000180879
Aliases signal sequence receptor subunit 4, translocon-associated protein delta
Synonyms CDG1Y, SIGNAL SEQUENCE receptor delta, signal sequence receptor, delta, signal sequence receptor subunit 4, SIGNAL SEQUENCE receptor δ, signal sequence receptor, δ, SSR-delta, SSR-δ, translocon-associated protein delta, translocon-associated protein δ, Trap, TRAPD, TRAP-delta, TRAP-δ
Species
Human, Homo sapiens
OrthologiesMouseRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SSR4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • Translocon-associated protein, delta subunit precursor (TRAP-delta)

Pathways

Biological processes and signaling networks where the SSR4 gene in human plays a role, providing insight into its function and relevance in health or disease.

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • congenital disorder of glycosylation type 1y
regulated by
  • CGA
  • NEF
  • corticosteroid
  • cyclosporin A
  • tetraethylammonium
  • HSP90B1
  • 5-fluorouracil
  • RARB
  • HECW1
  • Jurkat E6.1 cells

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Cytoplasm
  • Endoplasmic Reticulum
  • endoplasmic reticulum membrane

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the human SSR4 gene, providing context for its role in the cell.

Cellular Component

Where in the cell the gene product is active
  • extracellular vesicular exosome
  • endomembrane system
  • endoplasmic reticulum
  • Sec61 translocon complex

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.