Ap2m1 Gene Summary [Rat]
Enables low-density lipoprotein particle receptor binding activity and signal sequence binding activity. Involved in positive regulation of endocytosis; protein-containing complex assembly; and vesicle-mediated transport in synapse. Located in terminal bouton. Part of AP-2 adaptor complex. Is active in glutamatergic synapse and synaptic vesicle. Is extrinsic component of presynaptic endocytic zone membrane. Biomarker of heroin dependence. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder 60 with seizures. Orthologous to human AP2M1 (adaptor related protein complex 2 subunit mu 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ap2m1 |
| Official Name | adaptor related protein complex 2 subunit mu 1 [Source:RGD Symbol;Acc:620135] |
| Ensembl ID | ENSRNOG00000001709 |
| Bio databases IDs | |
| Aliases | adaptor related protein complex 2 subunit mu 1 |
| Synonyms | adaptor-related protein complex 2, mu 1 subunit, adaptor related protein complex 2 subunit mu 1, AP2M, AP2 mu, Ap2 Mu1, AP2 MU2, AP-2 mu2 subunit, AP50, CLAPM1, MRD60, mu2, Mu2 adaptin, Mu 2 subunit of AP-2 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ap2m1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- activation domain
- tyrosine binding pocket
- AP_MHD_Cterm
- protein binding activity, bridging
- ion channel binding
- Adaptor complexes medium subunit family
- linker domain
- protein domain specific binding
- protein binding
- low-density lipoprotein receptor binding
- Longin-like domains
- signal sequence binding
Pathways
Biological processes and signaling networks where the Ap2m1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- schizophrenia
- autosomal dominant intellectual developmental disorder with seizures type 60
- complex neurodevelopmental disorder
- infection by HIV-1
role in cell
- necrosis
- expression in
- apoptosis
- degradation in
- phosphorylation in
- migration
- accumulation in
- replication in
- downregulation in
- function in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- glutaminergic synapse
- endocytic vesicle membrane
- cellular membrane
- Plasma Membrane
- cytosol
- lysosome membrane
- endosomal membrane
- synaptic vesicles
- synapse
- secretory granules
- clathrin-coated pits
- clathrin-coated vesicles
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Ap2m1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- clathrin-mediated endocytosis
- vesicle-mediated transport
- membrane budding
- macromolecular complex assembly
- positive regulation of receptor internalization
- synaptic vesicle endocytosis
- positive regulation of synaptic vesicle endocytosis
- intracellular protein transport
- receptor internalization
Cellular Component
Where in the cell the gene product is active
- endolysosome membrane
- clathrin-coated endocytic vesicle
- lysosomal membrane
- plasma membrane
- internal side of plasma membrane
- clathrin-coated endocytic vesicle membrane
- extracellular vesicular exosome
- coated pit
- cytoplasmic vesicle
- cytosol
- AP-2 adaptor complex
- endocytic vesicle membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- low-density lipoprotein particle receptor binding
- clathrin adaptor activity
- lipid binding
- signal sequence binding
- ion channel binding