Clec7a Gene Summary [Rat]
Predicted to enable several functions, including (1->3)-beta-D-glucan binding activity; (1->3)-beta-D-glucan immune receptor activity; and identical protein binding activity. Predicted to be involved in several processes, including positive regulation of cytokine production; positive regulation of intracellular signal transduction; and response to fungus. Predicted to act upstream of or within several processes, including positive regulation of tumor necrosis factor production; regulation of calcineurin-NFAT signaling cascade; and response to fungus. Predicted to be located in cytoplasm and external side of plasma membrane. Predicted to be active in cell surface and plasma membrane. Human ortholog(s) of this gene implicated in aspergillosis and chronic mucocutaneous candidiasis. Orthologous to human CLEC7A (C-type lectin domain containing 7A). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Clec7a |
| Official Name | C-type lectin domain containing 7A [Source:RGD Symbol;Acc:1565140] |
| Ensembl ID | ENSRNOG00000054251 |
| Bio databases IDs | |
| Aliases | C-type lectin domain containing 7A |
| Synonyms | Beta-Glucan Receptor, beta-GR, BGR, CANDF4, CD369, Clec7, Clec7b, CLECSF12, C-type lectin domain containing 7A, C-type lectin domain family 7, member a, C-type lectin superfamily member 12, DECTIN1, RGD1565140, SCARE2, β-Glucan Receptor, β-GR |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Clec7a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- signaling receptor activity
- hemITAM motif
- C-type lectin (CTL)/C-type lectin-like (CTLD) domain
- Lectin C-type domain
- protein binding
- carbohydrate binding
- polysaccharide binding
- identical protein binding
- transmembrane receptor
Pathways
Biological processes and signaling networks where the Clec7a gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- papillary thyroid cancer
- neoplasia
- non-small cell lung carcinoma
- familial candidiasis type 4
- diabetic nephropathy
- diabetes mellitus
- psoriasis
- susceptibility to aspergillosis
- multiple system atrophy
- amyloidosis
role in cell
- production in
- expression in
- maturation
- differentiation
- proliferation
- phosphorylation in
- activation in
- activation
- number
- phagocytosis by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- membrane fraction
- Cytoplasm
- cell surface
- cellular membrane
- plasma membrane extracellular face
- perinuclear space
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Clec7a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- detection of molecule of fungal origin
- positive regulation of nitric oxide biosynthetic process
- positive regulation of monocyte chemotactic protein-1 production
- positive regulation of respiratory burst
- positive regulation of cell proliferation
- positive regulation of I-kappaB kinase/NF-kappaB cascade
- T cell activation
- regulation of I-kappaB kinase/NF-kappaB cascade
- positive regulation of sequence-specific DNA binding transcription factor activity
- positive regulation of NF-kappaB transcription factor activity
- positive regulation of cytokine production involved in inflammatory response
- carbohydrate mediated signaling
- defense response to protozoan
- stimulatory C-type lectin receptor signaling pathway
- positive regulation of calcium-mediated signaling
- positive regulation of T-helper 17 type immune response
- positive regulation of dendritic cell cytokine production
- inflammatory response
- phagocytosis, recognition
- positive regulation of interleukin-23 production
- positive regulation of interferon-gamma production
- positive regulation of tumor necrosis factor production
- regulation of calcineurin-NFAT signaling cascade
- positive regulation of protein complex assembly
- positive regulation of interleukin-2 production
- positive regulation of wound healing
- cell recognition
- positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
- positive regulation of cytokine production involved in immune response
- positive regulation of interleukin-8 production
- positive regulation of interleukin-12 production
- cell activation
- response to yeast
- innate immune response
- positive regulation of lymphocyte activation
- positive regulation of gene expression
- detection of yeast
- cellular response to molecule of fungal origin
- detection of fungus
- positive regulation of killing of cells of other organism
- positive regulation of interleukin-6 production
- positive regulation of phagocytosis
- positive regulation of interleukin-10 production
- positive regulation of interleukin-1 beta production
- positive regulation of cell migration
- positive regulation of superoxide anion generation
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- membrane
- plasma membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- (1->3)-beta-D-glucan binding
- protein binding
- metal ion binding
- MHC protein binding
- carbohydrate binding