Khdc3 Gene Summary [Rat]
Predicted to enable RNA binding activity. Predicted to be involved in several processes, including positive regulation of dendrite development; positive regulation of double-strand break repair via homologous recombination; and positive regulation of embryonic development. Predicted to act upstream of or within mitotic spindle assembly; mitotic spindle assembly checkpoint signaling; and protein phosphorylation. Predicted to be located in several cellular components, including cell cortex; centrosome; and mitochondrion. Predicted to be part of subcortical maternal complex. Human ortholog(s) of this gene implicated in gestational trophoblastic neoplasm. Orthologous to human KHDC3L (KH domain containing 3 like, subcortical maternal complex member). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Khdc3 |
| Official Name | KH domain containing 3, subcortical maternal complex member [Source:RGD Symbol;Acc:1311617] |
| Ensembl ID | ENSRNOG00000054460 |
| Bio databases IDs | |
| Aliases | KH domain containing 3, subcortical maternal complex member |
| Synonyms | 2410004A20Rik, C6orf221, ECAT1, FILIA, HYDM2, Khdc3, KH domain containing 3 like, subcortical maternal complex member, KH domain containing 3, subcortical maternal complex member, OEEP48, RGD1311617 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Khdc3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- K homology (KH) RNA-binding domain, type I
- KH-like RNA-binding domain
- protein binding
- structural molecule
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- recurrent hydatidiform mole type 2
- global developmental delay with intellectual disability
- familial recurrent hydatidiform mole
role in cell
- apoptosis
- organization
- development
- spindle checkpoint
- assembly
- processing
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- organelle
- cell cortex
- Nucleus
- centrosome
- Mitochondria
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Khdc3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of protein localization
- negative regulation of apoptotic process
- actin filament organization
- replication fork processing
- positive regulation of neurogenesis
- positive regulation of double-strand break repair
- positive regulation of embryonic development
- positive regulation of dendrite development
- establishment of organelle localization
Cellular Component
Where in the cell the gene product is active
- nucleus
- centrosome
- cytoplasm
- cell cortex
- mitochondrion
- macromolecular complex
- chromosome
Molecular Function
What the gene product does at the molecular level
- RNA binding
- protein binding