Foxp2 Gene Summary [Rat]
Enables nuclear androgen receptor binding activity. Involved in forebrain development; innate vocalization behavior; and response to testosterone. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in several diseases, including attention deficit hyperactivity disorder; autism spectrum disorder (multiple); communication disorder (multiple); dyslexia; and major depressive disorder. Orthologous to human FOXP2 (forkhead box P2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Foxp2 |
| Official Name | forkhead box P2 [Source:RGD Symbol;Acc:1559697] |
| Ensembl ID | ENSRNOG00000054508 |
| Bio databases IDs | |
| Aliases | forkhead box P2 |
| Synonyms | 2810043D05Rik, CAG-16, CAGH44, D0Kist7, forkhead box P2, RGD1559697, SPCH1, TNRC10 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Foxp2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- FH_FOX
- nucleic acid binding
- androgen receptor binding
- transcription factor binding
- leucine zipper domain
- protein binding
- sequence-specific DNA binding
- identical protein binding
- DNA binding
- Forkhead domain
- FORKHEAD
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional repressor activity
- FOXP coiled-coil domain
- double-stranded DNA binding
- protein homodimerization
- transcription factor activity
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- epithelial cancer
- osteoarthritis
- isolated childhood apraxia of speech
- hereditary disorder
- insomnia
- metabolic syndrome X
- post-traumatic stress disorder
- opioid-related disorder
- schizophrenia
role in cell
- expression in
- proliferation
- apoptosis
- phosphorylation in
- number
- colony formation by
- growth
- migration
- abnormal morphology
- genesis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Foxp2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- negative regulation of transcription, DNA-dependent
- caudate nucleus development
- putamen development
- cerebral cortex development
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- chromatin
Molecular Function
What the gene product does at the molecular level
- DNA binding
- sequence-specific DNA binding transcription factor activity
- identical protein binding
- protein homodimerization activity
- protein binding
- metal ion binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
- sequence-specific DNA binding RNA polymerase II transcription factor activity