Hif3a Gene Summary [Rat]
Enables DNA-binding transcription factor activity. Involved in positive regulation of transcription by RNA polymerase II. Predicted to be located in several cellular components, including chromatin; mitochondrion; and nuclear speck. Biomarker of pulmonary hypertension. Orthologous to human HIF3A (hypoxia inducible factor 3 subunit alpha). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Hif3a |
| Official Name | hypoxia inducible factor 3 subunit alpha [Source:RGD Symbol;Acc:70332] |
| Ensembl ID | ENSRNOG00000017198 |
| Bio databases IDs | |
| Aliases | hypoxia inducible factor 3 subunit alpha |
| Synonyms | bHLHe17, HIF-3 alpha, HIF-3 α, hypoxia inducible factor 3, alpha subunit, hypoxia inducible factor 3 subunit alpha, hypoxia inducible factor 3 subunit α, hypoxia inducible factor 3, α subunit, IPAS, MOP7, Nepas, PASD7 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Hif3a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- Hypoxia-inducible factor-1
- nucleic acid binding
- PAS
- basic Helix Loop Helix (bHLH) domain superfamily
- protein binding
- sequence-specific DNA binding
- PAS fold
- DNA binding
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- double-stranded DNA binding
- PAS domain
- helix loop helix domain
- oxygen-dependent degradation domain
- Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain)
- transcription factor activity
Pathways
Biological processes and signaling networks where the Hif3a gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- androgenic alopecia
- kidney carcinoma
- renal cancer
- idiopathic pulmonary fibrosis
regulated by
- insulin
- NFkB (complex)
- Pam3-Cys-Ser-Lys4
- AKT
- TGF beta
- corticosterone
- magnesium
- HIF1A
- endothelial cells
- cobalt chloride
role in cell
- expression in
- growth
- cell viability
- phosphorylation in
- quantity
- migration
- activation in
- interaction in
- transactivation in
- ubiquitination in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- Plasma Membrane
- Mitochondria
- cytosol
- nucleoplasm
- nuclear speckles
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Hif3a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to hypoxia
- angiogenesis
- apoptotic process
- transcription from RNA polymerase II promoter
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nuclear speck
- mitochondrion
- cytosol
- chromatin
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- RNA polymerase II regulatory region sequence-specific DNA binding
- protein dimerization activity
- sequence-specific DNA binding RNA polymerase II transcription factor activity