Mir509 Gene Summary [Rat]
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Details
| Type | Micro RNA |
| Official Symbol | Mir509 |
| Official Name | microRNA 509 [Source:RGD Symbol;Acc:7489026] |
| Ensembl ID | ENSRNOG00000054747 |
| Bio databases IDs | |
| Aliases | microRNA 509 |
| Synonyms | hsa-miR-506, hsa-mir-507, hsa-miR-508, hsa-miR-509, hsa-mir-509-1, hsa-mir-509-2, hsa-mir-509-3, hsa-miR-509-3p-2, hsa-miR-509-3p-3, hsa-miR-510, hsa-miR-511, hsa-mir-511-1, hsa-mir-511-2, hsa-mir-512-1, hsa-mir-512-2, hsa-miR-513, hsa-mir-513-1, hsa-mir-513-2, hsa-mir-513a-1, hsa-mir-513a-2, hsa-miR-513b, hsa-miR-513c, hsa-miR-514, hsa-mir-514-1, hsa-mir-514-2, hsa-mir-514-3, hsa-mir-514a-1, hsa-mir-514a-2, hsa-mir-514a-3, hsa-mir-514b, MI0003128, MI0012586, microRNA 3585, microRNA 449ab, microRNA 506, microRNA 507, microRNA 508, microRNA 509, microRNA 509-1, microRNA 509-2, microRNA 509-3, microRNA 510, microRNA 511, microRNA 511-1, microRNA 512, microRNA 512-1, microRNA 512-2, microRNA 513-1, microRNA 513-2, microRNA 513a-1, microRNA 513a-2, microRNA 513b, microRNA 513c, microRNA 514-1, microRNA 514-2, microRNA 514-3, microRNA 514a-1, microRNA 514a-2, microRNA 514a-3, microRNA 514b, Mir3585, MIR506-514, miR-506-514 cluster, MIR507, MIR508, MIR509, MIR509-1, MIR509-2, MIR509-3, MIR510, MIR511, MIR511-1, MIR511-2, MIR512, MIR512-1, MIR512-2, MIR513A, MIR513A1, MIR513A2, MIR513B, MIR513C, miR-514, MIR514-1, MIR514-2, MIR514-3, MIR514A, MIR514A1, MIR514A2, MIR514A3, MIR514B, MIRN506, MIRN507, MIRN508, MIRN509, MIRN509-1, MIRN509-2, MIRN509-3, MIRN510, Mirn511, MIRN511-1, MIRN511-2, MIRN512-1, MIRN512-2, MIRN513-1, MIRN513-2, MIRN513A1, MIRN513A-2, MIRN513B, MIRN513C, MIRN514-1, MIRN514-2, MIRN514-3, mmu-mir-509, mmu-miR-511, rno-mir-3585, rno-mir-509, rno-mir-513 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Mir509 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- mRNA 3' UTR binding
- translation repressor
- mRNA binding
- microRNA
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- bladder neoplasm
- bladder neoplasia
- neoplastic cell transformation
- metastasis
- organismal death
- skin cancer
- nonobstructive azoospermia
- post-infectious irritable bowel syndrome
- hepatocellular carcinoma
role in cell
- expression in
- apoptosis
- proliferation
- survival
- cell viability
- migration
- quantity
- invasion by
- autophagy in
- transendothelial migration
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm