Sfrp4 Gene Summary [Rat]
Enables Wnt-protein binding activity. Involved in several processes, including decidualization; mammary gland involution; and negative regulation of signal transduction. Located in extracellular space. Human ortholog(s) of this gene implicated in metaphyseal dysplasia. Orthologous to human SFRP4 (secreted frizzled related protein 4). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Sfrp4 |
| Official Name | secreted frizzled-related protein 4 [Source:RGD Symbol;Acc:621075] |
| Ensembl ID | ENSRNOG00000054957 |
| Bio databases IDs | |
| Aliases | secreted frizzled-related protein 4 |
| Synonyms | Frp, FRP-4, FRPHE, FRZB-2, PYL, secreted frizzled-related protein 4 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Sfrp4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- NTR_like
- Wnt-protein binding
- Fz domain
- protein binding
- transmembrane receptor
- CRD_domain cysteine-rich domain, also known as Fz (frizzled) domain
Pathways
Biological processes and signaling networks where the Sfrp4 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- weight gain
- Dupuytren contracture
- Pyle type metaphyseal dysplasia
- endometriosis
- autosomal dominant polycystic kidney disease
- primary angle-closure glaucoma
- systemic sclerosis
- atresia
- head and neck neuroendocrine neoplasia
role in cell
- expression in
- number
- formation
- signaling in
- proliferation
- migration
- growth
- differentiation
- apoptosis
- genesis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- cell surface
- Extracellular Space
- Nucleus
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Sfrp4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- phosphate ion homeostasis
- positive regulation of epidermal cell differentiation
- positive regulation of receptor internalization
- negative regulation of cell proliferation
- negative regulation of non-canonical Wnt receptor signaling pathway
- positive regulation of canonical Wnt receptor signaling pathway
- bone morphogenesis
- negative regulation of sequence-specific DNA binding transcription factor activity
- response to hormone stimulus
- negative regulation of canonical Wnt receptor signaling pathway
- negative regulation of sodium-dependent phosphate transport
- positive regulation of gene expression
- positive regulation of apoptotic process
- cell differentiation
- canonical Wnt receptor signaling pathway
- negative regulation of Wnt receptor signaling pathway
- regulation of BMP signaling pathway
- non-canonical Wnt receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- nucleus
- extracellular space
- cytoplasm
- cell surface
Molecular Function
What the gene product does at the molecular level
- protein binding
- Wnt-protein binding