Birc5 Gene Summary [Rat]
Predicted to enable several functions, including cysteine-type endopeptidase inhibitor activity involved in apoptotic process; protein dimerization activity; and small GTPase binding activity. Involved in several processes, including cellular response to ethanol; cellular response to stem cell factor stimulus; and response to glucocorticoid. Located in apical plasma membrane. Used to study endometriosis and pulmonary hypertension. Biomarker of acute pancreatitis (multiple); artery disease (multiple); congestive heart failure; high grade glioma; and stomach carcinoma. Human ortholog(s) of this gene implicated in prostate cancer and transitional cell carcinoma. Orthologous to human BIRC5 (baculoviral IAP repeat containing 5). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Birc5 |
| Official Name | baculoviral IAP repeat-containing 5 [Source:RGD Symbol;Acc:70499] |
| Ensembl ID | ENSRNOG00000050819 |
| Bio databases IDs | |
| Aliases | baculoviral IAP repeat-containing 5 |
| Synonyms | AAC-11, AP14, API4, baculoviral IAP repeat-containing 5, EPR-1, Survivin, SURVIVIN 2B, TIAP |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Birc5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- dimerization domain
- Bir domain
- plk1 phosphorylation site
- caspase inhibitor activity
- enzyme binding
- coiled-coil domain
- protein binding
- identical protein binding
- phosphorylation site
- microtubule binding
- BIR
- zinc ion binding
- tubulin binding
- protein homodimerization
- chaperone binding
- protein heterodimerization
Pathways
Biological processes and signaling networks where the Birc5 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- breast cancer
- systemic lupus erythematosus
- organismal death
- childhood medulloblastoma
- brain cancer
- pediatric cancer
- prostate cancer
- abdominal cancer
- epithelial cancer
role in cell
- binding in
- apoptosis
- proliferation
- growth
- cell viability
- chromosomal congression
- maturation
- G1 phase
- mitosis
- migration
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- nuclear fraction
- mitochondrial fraction
- microtubule cytoskeleton
- perinuclear membrane
- actin cytoskeleton
- Nucleus
- centrosome
- Golgi Apparatus
- centriole
- Mitochondria
- midbody
- cytoplasmic particles
- microtubule organizing centers
- metaphase plate
- cytosol
- centromeric region
- membrane ruffles
- apical membrane
- chromosome
- nucleoplasm
- spindle pole
- spindle fibers
- cytoplasmic microtubule
- polar microtubule
- cleavage furrow
- central spindle
- mitotic spindle
- kinetochores
- centromeres
- cytoplasmic fraction
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Birc5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of mitotic cell cycle spindle assembly checkpoint
- positive regulation of cell proliferation
- protein phosphorylation
- mitotic cell cycle
- sensory perception of sound
- protein complex localization
- spindle midzone assembly involved in mitosis
- negative regulation of transcription, DNA-dependent
- cytokinesis after mitosis
- negative regulation of apoptotic process
- apoptotic process
- spindle assembly involved in mitosis
Cellular Component
Where in the cell the gene product is active
- microtubule cytoskeleton
- nuclear chromosome
- kinetochore
- chromosome, centromeric region
- microtubule
- nucleoplasm
- nucleus
- cytoplasm
- spindle
- cytosol
- chromosome passenger complex
- midbody
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- cysteine-type endopeptidase inhibitor activity
- metal ion binding
- chaperone binding
- small GTPase binding
- microtubule binding
- enzyme binding