Ncapd2 Gene Summary [Rat]
Predicted to enable histone binding activity. Predicted to be involved in chromosome condensation; positive regulation of chromosome condensation; and regulation of chromosome segregation. Predicted to be located in cytosol; microtubule organizing center; and nucleus. Predicted to be part of condensin complex. Predicted to be active in condensed chromosome, centromeric region. Human ortholog(s) of this gene implicated in primary autosomal recessive microcephaly 21. Orthologous to human NCAPD2 (non-SMC condensin I complex subunit D2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ncapd2 |
| Official Name | non-SMC condensin I complex, subunit D2 [Source:RGD Symbol;Acc:1562596] |
| Ensembl ID | ENSRNOG00000055300 |
| Bio databases IDs | |
| Aliases | non-SMC condensin I complex, subunit D2 |
| Synonyms | 2810406C15Rik, 2810465G24Rik, CAP-D2, CNAP1, hCAP-D2, MCPH21, mKIAA0159, non-SMC condensin I complex subunit D2, non-SMC condensin I complex, subunit D2, RGD1562596 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ncapd2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- non-SMC mitotic condensation complex subunit 1
- histone binding
- nuclear localization sequence
- protein binding
- non-SMC mitotic condensation complex subunit 1, N-term
- Mitotic chromosome targeting domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hereditary disorder
- autosomal recessive primary microcephaly type 21
- lymphomagenesis
- MYC mutation positive B-cell lymphoma
- B cell cancer
- microcephaly
regulates
role in cell
- growth
- quantity
- resolution
- condensation
- segregation
- alignment
- aneuploidy
- disorganization
- association
- structure
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- basal bodies
- centrosome
- cytosol
- nuclear foci
- chromosome
- nucleoplasm
- pronucleus
- chromosomal arms
- chromatin
- cytoplasmic fraction
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Ncapd2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell division
- positive regulation of chromosome segregation
- meiotic chromosome condensation
- mitotic chromosome condensation
Cellular Component
Where in the cell the gene product is active
- condensed chromosome
- nucleus
- cytoplasm
- membrane
- condensed chromosome, centromeric region
- nuclear chromosome
- cytosol
- condensin complex
- condensed nuclear chromosome
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- histone binding