Bmp1 Gene Summary [Rat]
Predicted to enable identical protein binding activity and metalloendopeptidase activity. Predicted to be involved in dorsal/ventral pattern formation and protein processing. Predicted to act upstream of or within positive regulation of cartilage development. Located in extracellular space and vesicle. Human ortholog(s) of this gene implicated in osteogenesis imperfecta type 13. Orthologous to human BMP1 (bone morphogenetic protein 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Bmp1 |
| Official Name | bone morphogenetic protein 1 [Source:RGD Symbol;Acc:620739] |
| Ensembl ID | ENSRNOG00000010890 |
| Bio databases IDs | |
| Aliases | bone morphogenetic protein 1 |
| Synonyms | bone morphogenetic protein 1, OI13, PCOLC, PCP, PCP2, Procollagen C Proteinase, Tld |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Bmp1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- procollagen C-endopeptidase
- metalloprotease domain
- peptidase
- Astacin (Peptidase family M12A)
- Zinc-dependent metalloprotease
- protein binding
- identical protein binding
- EGF-like domain
- EGF_CA
- ZnMc
- protease domain
- serine endopeptidase
- CUB
- EGF domain
- Coagulation Factor Xa inhibitory site
- metalloendopeptidase
Pathways
Biological processes and signaling networks where the Bmp1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
- Axonal Guidance Signaling
- Basal Cell Carcinoma Signaling
- BMP signaling pathway
- Factors Promoting Cardiogenesis in Vertebrates
- Human Embryonic Stem Cell Pluripotency
- Iron homeostasis signaling pathway
- Molecular Mechanisms of Cancer
- Role of NANOG in Mammalian Embryonic Stem Cell Pluripotency
- Role of Osteoblasts, Osteoclasts and Chondrocytes in Rheumatoid Arthritis
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- diabetic nephropathy
- cancer
- epithelial cancer
- metastasis
- breast cancer
- organismal death
- neoplasia
- osteogenesis imperfecta type XIII
- rheumatoid arthritis
- glioblastoma
role in cell
- expression in
- apoptosis
- production in
- differentiation
- growth
- organization
- deposition by
- molecular cleavage in
- processing in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- S-layer
- Cytoplasm
- vesicles
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Bmp1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of cartilage development
- skeletal system development
- cartilage condensation
- signal transduction
- ossification
- proteolysis
- cell differentiation
- protein processing
- collagen fibril organization
- dorsal/ventral pattern formation
Cellular Component
Where in the cell the gene product is active
- extracellular space
- vesicle
- Golgi apparatus
- extracellular region
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- identical protein binding
- growth factor activity
- protein binding
- calcium ion binding
- serine-type endopeptidase activity
- peptidase activity
- cytokine activity
- metalloendopeptidase activity
- metallopeptidase activity