Sftpd Gene Summary [Rat]
Enables identical protein binding activity; lipopolysaccharide binding activity; and monosaccharide binding activity. Involved in several processes, including negative regulation of interleukin-2 production; opsonization; and regulation of phagocytosis. Located in extracellular space and multivesicular body. Biomarker of Coronavirus infectious disease; asthma; bacterial pneumonia; lung disease; and newborn respiratory distress syndrome. Human ortholog(s) of this gene implicated in asthma; lung disease (multiple); respiratory syncytial virus infectious disease; and rhinitis. Orthologous to human SFTPD (surfactant protein D). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Sftpd |
| Official Name | surfactant protein D [Source:RGD Symbol;Acc:3667] |
| Ensembl ID | ENSRNOG00000056001 |
| Bio databases IDs | |
| Aliases | surfactant protein D |
| Synonyms | COLEC7, PSP-D, Sfpd, SFTP4, SP-D, surfactant associated protein D, surfactant protein D |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Sftpd often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- collagen-like domain
- C-type lectin (CTL)/C-type lectin-like (CTLD) domain
- carbohydrate recognition domain
- signal peptide
- protein binding
- identical protein binding
- lipopolysaccharide binding
- collagen homology domain
- monosaccharide binding
- Lectin C-type domain
- Lung surfactant protein D coiled-coil trimerization
- Collagen triple helix repeat (20 copies)
- neck domain
- carbohydrate binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- COVID-19
- pneumonitis
- pulmonary emphysema
- non-insulin-dependent diabetes mellitus
- chronic obstructive pulmonary disease
- lung adenocarcinoma
- lung adenocarcinoma formation
- rheumatoid arthritis
- prostate cancer
- infection
role in cell
- production in
- number
- activation in
- recruitment
- immune response
- quantity
- cell death
- phosphorylation in
- hemagglutination
- cell viability
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Cytoplasm
- cell surface
- lysosome
- endoplasmic reticulum membrane
- endocytotic vesicle
- multivesicular bodies
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Sftpd gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- respiratory gaseous exchange
- receptor-mediated endocytosis
- defense response to bacterium
- surfactant homeostasis
- reactive oxygen species metabolic process
- lung alveolus development
- negative regulation of interleukin-2 production
- macrophage chemotaxis
- negative regulation of T cell proliferation
- innate immune response
- regulation of cytokine production
- positive regulation of phagocytosis
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- endocytic vesicle
- extracellular space
- collagen
- multivesicular body
- clathrin-coated endocytic vesicle
- extracellular region
- lysosome
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- carbohydrate binding