Itgb4 Gene Summary [Rat]
Predicted to enable G protein-coupled receptor binding activity and integrin binding activity. Predicted to contribute to insulin-like growth factor I binding activity and neuregulin binding activity. Predicted to be involved in several processes, including hemidesmosome assembly; integrin-mediated signaling pathway; and skin morphogenesis. Predicted to act upstream of or within several processes, including filopodium assembly; peripheral nervous system myelin formation; and trophoblast cell migration. Located in cell cortex. Is active in glutamatergic synapse and postsynaptic membrane. Human ortholog(s) of this gene implicated in junctional epidermolysis bullosa and junctional epidermolysis bullosa with pyloric atresia. Orthologous to human ITGB4 (integrin subunit beta 4). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Itgb4 |
| Official Name | integrin subunit beta 4 [Source:RGD Symbol;Acc:2928] |
| Ensembl ID | ENSRNOG00000005580 |
| Bio databases IDs | |
| Aliases | integrin subunit beta 4 |
| Synonyms | AA407042, beta4 integrin, C230078O20, CD104, GP150, integrin beta 4, integrin subunit beta 4, integrin subunit β 4, Integrin-β 4, JEB5A, JEB5B, β4 integrin |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Itgb4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Integrin beta chain VWA domain
- Integrin plexin domain
- cell adhesion molecule binding
- G-protein-coupled receptor binding
- insulin-like growth factor binding
- Fibronectin type 3 domain
- Domains in Na-Ca exchangers and integrin-beta4
- EGF_CA
- Integrin beta tail domain
- cytoplasmic domain
- immunoreceptor tyrosine-based inhibition motif
- vWFA
- intracellular domain
- Calx-beta domain
- transmembrane receptor
- growth factor binding
- extracellular domain
- ectodomain
- tyrosine activation motif
- protein binding
- Integrin beta subunits (N-terminal portion of extracellular region)
- phosphorylation site
- FN3
- transmembrane domain
- cytosolic tail domain
- tyrosine phosphorylation site
- Integrin beta epidermal growth factor like domain 1
- specificity-determining loop
Pathways
Biological processes and signaling networks where the Itgb4 gene in rat plays a role, providing insight into its function and relevance in health or disease.
- Actin Cytoskeleton Signaling
- Actin Nucleation by ARP-WASP Complex
- Caveolar-mediated Endocytosis Signaling
- Clathrin-mediated Endocytosis Signaling
- Ephrin Receptor Signaling
- ERK/MAPK Signaling
- HER-2 Signaling in Breast Cancer
- HGF Signaling
- ILK Signaling
- Integrin Signaling
- Macropinocytosis Signaling
- PAK Signaling
- Paxillin Signaling
- PTEN Signaling
- Rac Signaling
- Regulation of Actin-based Motility by Rho
- Regulation of Cellular Mechanics by Calpain Protease
- Regulation of eIF4 and p70S6K Signaling
- RhoGDI Signaling
- Sertoli Cell-Sertoli Cell Junction Signaling
- Tec Kinase Signaling
- Virus Entry via Endocytic Pathways
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Huntington disease
- neoplasia
- metastasis
- cancer
- junctional epidermolysis bullosa with pyloric atresia
- plaque psoriasis
- endometriosis
- intermediate junctional epidermolysis bullosa type 5A
- lung squamous cell carcinoma
- squamous cell lung cancer
role in cell
- phosphorylation in
- activation in
- apoptosis
- growth
- proliferation
- expression in
- differentiation
- quantity
- degradation in
- cell death
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- glutaminergic synapse
- cell junction
- hemidesmosome-like structure
- extracellular vesicles
- Cytoplasm
- cell-substratum contacts
- cell surface
- Extracellular Space
- cell periphery
- basal compartment
- cellular membrane
- retraction fibers
- cell cortex
- hemidesmosomes
- granules
- postsynaptic membrane
- basal membrane
- cell membrane-lagging edges
- lateral plasma membrane
- nucleoli
- nuclear envelope
- filopodia
- cell membrane leading edge
- exosomes
- basement membrane
- lamellipodia
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Itgb4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell-matrix adhesion
- peripheral nervous system myelin formation
- hemidesmosome assembly
- response to wounding
- cell adhesion
- skin morphogenesis
- filopodium assembly
- cell motility
- cell adhesion mediated by integrin
- integrin-mediated signaling pathway
- mesodermal cell differentiation
- autophagy
- nail development
- cell migration
Cellular Component
Where in the cell the gene product is active
- cell leading edge
- receptor complex
- nucleolus
- integrin complex
- plasma membrane
- cell surface
- nuclear membrane
- basal plasma membrane
- basement membrane
- extracellular vesicular exosome
- focal adhesion
- cell junction
- hemidesmosome
Molecular Function
What the gene product does at the molecular level
- G-protein coupled receptor binding
- protein binding
- neuregulin binding
- metal ion binding
- integrin binding
- insulin-like growth factor I binding