Nme8 Gene Summary [Rat]
Predicted to enable 3'-5' exonuclease activity and microtubule binding activity. Predicted to be involved in cilium assembly and flagellated sperm motility. Predicted to act upstream of or within cellular response to reactive oxygen species. Located in sperm fibrous sheath. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia 6. Orthologous to human NME8 (NME/NM23 family member 8). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Nme8 |
| Official Name | NME/NM23 family member 8 [Source:RGD Symbol;Acc:735069] |
| Ensembl ID | ENSRNOG00000058285 |
| Bio databases IDs | |
| Aliases | NME/NM23 family member 8 |
| Synonyms | 1700056P15Rik, CILD6, DNAI8, HEL-S-99, NM23-H8, NME/NM23 family member 8, SPTRX2, TXNDC3 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Nme8 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- microtubule binding
- nucleoside diphosphate kinase
- 3'-5' exonuclease
- Nucleoside diphosphate kinase family
- NDPk
- Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold
- thioredoxin
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- axonemes
- fibrous sheath of sperm
- cytosol
- nuclear speckles
- sperm midpiece
- sperm tail
- sperm fibrous sheath
- cytoplasmic droplets
- residual bodies
- cytoplasmic vesicles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Nme8 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- sperm motility
- cilium morphogenesis
- spermatogenesis
- cell differentiation
- cellular response to reactive oxygen species
Cellular Component
Where in the cell the gene product is active
- nucleus
- outer dynein arm
- sperm midpiece
- cytoplasm
- nuclear speck
- cytosol
- sperm principal piece
- axoneme
Molecular Function
What the gene product does at the molecular level
- 3'-5' exonuclease activity
- microtubule binding