Nme8 Gene Summary [Mouse]
Predicted to enable 3'-5' exonuclease activity and microtubule binding activity. Acts upstream of or within cellular response to reactive oxygen species and flagellated sperm motility. Located in axoneme; sperm cytoplasmic droplet; and sperm principal piece. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia 6. Orthologous to human NME8 (NME/NM23 family member 8). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | Nme8 |
| Official Name | NME/NM23 family member 8 [Source:MGI Symbol;Acc:MGI:1920662] |
| Ensembl ID | ENSMUSG00000041138 |
| Bio databases IDs | |
| Aliases | NME/NM23 family member 8 |
| Synonyms | 1700056P15Rik, CILD6, DNAI8, HEL-S-99, NM23-H8, NME/NM23 family member 8, SPTRX2, TXNDC3 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Nme8 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- microtubule binding
- nucleoside diphosphate kinase
- 3'-5' exonuclease
- Nucleoside diphosphate kinase family
- NDPk
- Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold
- thioredoxin
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- axonemes
- fibrous sheath of sperm
- cytosol
- nuclear speckles
- sperm midpiece
- sperm tail
- sperm fibrous sheath
- cytoplasmic droplets
- residual bodies
- cytoplasmic vesicles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Nme8 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- sperm motility
- cilium morphogenesis
- spermatogenesis
- cell differentiation
- cellular response to reactive oxygen species
Cellular Component
Where in the cell the gene product is active
- nucleus
- outer dynein arm
- sperm midpiece
- cytoplasm
- nuclear speck
- cytosol
- sperm principal piece
- axoneme
Molecular Function
What the gene product does at the molecular level
- 3'-5' exonuclease activity
- microtubule binding