Cys1 Gene Summary [Rat]
Predicted to enable chromatin binding activity and transcription corepressor activity. Predicted to be involved in negative regulation of DNA-templated transcription. Predicted to act upstream of or within inner ear development; kidney development; and regulation of DNA-templated transcription. Predicted to be located in several cellular components, including cytoskeleton; cytosol; and nucleus. Orthologous to human CYS1 (cystin 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cys1 |
| Official Name | cystin 1 [Source:RGD Symbol;Acc:1596023] |
| Ensembl ID | ENSRNOG00000058891 |
| Bio databases IDs | |
| Aliases | cystin 1 |
| Synonyms | 2900006B19Rik, CCAP, Cilia-Associated, ck, CPK, CYSTIN, cystin 1, LOC686584 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Cys1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- transcription co-repressor
- chromatin binding
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- chronic obstructive pulmonary disease
- chronic bronchitis
- gout
- polycystic kidney disease
- autosomal recessive polycystic kidney disease
regulates
- DNA promoter
- DNA endogenous promoter
- PKHD1
- RNA polymerase II
- SCNN1A
role in cell
- expression in
- ubiquitination in
- architecture
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cilia
- cell surface
- cellular membrane
- Nucleus
- basal bodies
- axonemes
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Cys1 gene, providing context for its role in the cell.
Cellular Component
Where in the cell the gene product is active
- cytoskeleton
- cilium
- cytosol
- cilium membrane
Molecular Function
What the gene product does at the molecular level
- protein binding