Shld2 Gene Summary [Rat]
Predicted to be involved in negative regulation of double-strand break repair via homologous recombination; positive regulation of double-strand break repair via nonhomologous end joining; and positive regulation of isotype switching. Predicted to be located in actin cytoskeleton; chromosome; and nucleoplasm. Predicted to be active in nucleus and site of double-strand break. Orthologous to human SHLD2 (shieldin complex subunit 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Shld2 |
| Official Name | shieldin complex subunit 2 [Source:RGD Symbol;Acc:1565067] |
| Ensembl ID | ENSRNOG00000059057 |
| Bio databases IDs | |
| Aliases | shieldin complex subunit 2 |
| Synonyms | 3110001K24Rik, bA163M19.1, FAM35A, FAM35A1, RGD1310009, RINN2, shieldin complex subunit 2 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Shld2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Protein family FAM35, C-terminal
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- actin cytoskeleton
- Nucleus
- chromosome
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Shld2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- DNA repair
- negative regulation of double-strand break repair via homologous recombination
- somatic diversification of immunoglobulins involved in immune response
- positive regulation of isotype switching
- regulation of double-strand break repair via homologous recombination
- positive regulation of double-strand break repair via nonhomologous end joining
- telomere maintenance in response to DNA damage
Cellular Component
Where in the cell the gene product is active
- nucleus
- site of double-strand break
- actin cytoskeleton
- chromosome
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding