Cetn2 Gene Summary [Rat]
Caltractin belongs to a family of calcium-binding proteins and is a structural component of the centrosome. The high level of conservation from algae to humans and its association with the centrosome suggested that caltractin plays a fundamental role in the structure and function of the microtubule-organizing center, possibly required for the proper duplication and segregation of the centrosome. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | Cetn2 |
| Official Name | centrin 2 [Source:RGD Symbol;Acc:620247] |
| Ensembl ID | ENSRNOG00000059593 |
| Bio databases IDs | |
| Aliases | centrin 2 |
| Synonyms | 1110034A02Rik, CALT, CALTRACTIN, CEN2, centrin 2 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Cetn2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- EF-hand, calcium binding motif
- EF-hand domain pair
- calcium ion binding
- EFh
- enzyme
- protein binding
- EFh_MICU
- EFh_PI-PLC
- microtubule binding
- EF-hand domain
- binding protein
- EF hand
- EF-hand, calcium binding motif, found in parvalbumin-like EF-hand family
Pathways
Biological processes and signaling networks where the Cetn2 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Huntington disease
- retinal degeneration
- hydrocephalus
- weight loss
- dysosmia
role in cell
- accumulation in
- loss
- pluripotency
- abnormal morphology
- ciliogenesis in
- duplication
- cytokinesis in
- repair in
- replication
- 5-fluorouracil resistance
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- motile cilia
- Cytoplasm
- cilia
- apical compartment
- basal bodies
- centrosome
- centriole
- cytosol
- connecting cilia
- nucleoplasm
- glial cell projections
- perikaryon
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Cetn2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell division
- centriole replication
- spermatogenesis
- protein transport
- regulation of cytokinesis
- nucleotide-excision repair
- mRNA transport
- mitotic cell cycle
Cellular Component
Where in the cell the gene product is active
- photoreceptor connecting cilium
- nucleus
- centrosome
- apical part of cell
- cilium basal body
- centriole
- XPC complex
- cytosol
- transcription export complex 2
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- calcium ion binding
- heterotrimeric G-protein binding
- G-protein beta/gamma-subunit complex binding
- microtubule binding