Oas3 Gene Summary [Rat]
Predicted to enable 2'-5'-oligoadenylate synthetase activity; ATP binding activity; and double-stranded RNA binding activity. Predicted to be involved in several processes, including innate immune response; regulation of cytokine production; and regulation of innate immune response. Predicted to be located in cytoplasm and plasma membrane. Predicted to be active in cytosol; membrane; and nucleoplasm. Orthologous to human OAS3 (2'-5'-oligoadenylate synthetase 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Oas3 |
| Official Name | 2'-5'-oligoadenylate synthetase 3 [Source:RGD Symbol;Acc:1359319] |
| Ensembl ID | ENSRNOG00000059207 |
| Bio databases IDs | |
| Aliases | 2'-5'-oligoadenylate synthetase 3 |
| Synonyms | 2',5'-OAS, 2'-5'-oligoadenylate synthetase 3, Oasl10, OAS p100, p100, p100OAS |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Oas3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- 2'-5'-oligoadenylate synthetase 1, domain 2, C-terminus
- Nucleotidyltransferase (NT) domain of DNA polymerase beta and similar proteins
- ATP binding
- double-stranded RNA binding
- enzyme
- protein binding
- 2'-5'-oligoadenylate synthetase
Pathways
Biological processes and signaling networks where the Oas3 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hypertension
- myocardial infarction
- cervical intraepithelial neoplasia
- COVID-19
- diverticular disease of colon
- complete testicular feminization syndrome
- acute myeloid leukemia
- dermatomyositis
- systemic lupus erythematosus
- relapsing-remitting multiple sclerosis
role in cell
- activation in
- apoptosis
- cell death
- degradation in
- growth
- replication in
- synthesis in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- intracellular membrane-bounded organelle
- Plasma Membrane
- cytosol
- nucleoplasm
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Oas3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of monocyte chemotactic protein-1 production
- MDA-5 signaling pathway
- negative regulation of chemokine (C-X-C motif) ligand 9 production
- negative regulation of type I interferon-mediated signaling pathway
- response to virus
- defense response to bacterium
- nucleobase-containing compound metabolic process
- regulation of ribonuclease activity
- innate immune response
- positive regulation of interferon-beta production
- negative regulation of chemokine (C-C motif) ligand 5 production
- RIG-I signaling pathway
- defense response to virus
- positive regulation of tumor necrosis factor production
- negative regulation of chemokine (C-X-C motif) ligand 2 production
- negative regulation of IP-10 production
- negative regulation of viral genome replication
Cellular Component
Where in the cell the gene product is active
- extracellular space
- cytoplasm
- intracellular membrane-bounded organelle
- membrane
- cytosol
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- 2'-5'-oligoadenylate synthetase activity
- ATP binding
- protein binding
- double-stranded RNA binding
- metal ion binding