Dnase2 Gene Summary [Rat]
Enables DNA endonuclease activity. Predicted to be involved in apoptotic DNA fragmentation. Predicted to act upstream of or within DNA catabolic process; enucleate erythrocyte differentiation; and regulation of immune response. Predicted to be located in lysosome. Orthologous to human DNASE2 (deoxyribonuclease 2, lysosomal). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Dnase2 |
| Official Name | deoxyribonuclease 2, lysosomal [Source:RGD Symbol;Acc:621457] |
| Ensembl ID | ENSRNOG00000023830 |
| Bio databases IDs | |
| Aliases | deoxyribonuclease 2, lysosomal |
| Synonyms | AIPCS, deoxyribonuclease 2, lysosomal, deoxyribonuclease II alpha, deoxyribonuclease II α, DNASE2A, DNASE II, Dnase ii, lysosomal, DNL, DNL2 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Dnase2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- endonuclease
- enzyme
- protein binding
- deoxyribonuclease II
- Catalytic domain of phospholipase D superfamily proteins
- DNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- rheumatoid arthritis
- cancer
- epithelial cancer
- arthritis
- glioblastoma
- glioblastoma cancer
- liver cancer
- anemia
- autoinflammatory-pancytopenia syndrome
- glioma formation
role in cell
- apoptosis
- expression in
- differentiation
- number
- phagocytosis by
- accumulation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- phagolysosome
- lysosome
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Dnase2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- apoptotic DNA fragmentation
- enucleate erythrocyte differentiation
- DNA metabolic process
- regulation of immune response
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- lysosome
Molecular Function
What the gene product does at the molecular level
- DNA binding
- deoxyribonuclease II activity