OAS3 Gene Summary [Human]
This gene encodes an enzyme included in the 2', 5' oligoadenylate synthase family. This enzyme is induced by interferons and catalyzes the 2', 5' oligomers of adenosine in order to bind and activate RNase L. This enzyme family plays a significant role in the inhibition of cellular protein synthesis and viral infection resistance. [provided by RefSeq, Jul 2008]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | OAS3 |
| Official Name | 2'-5'-oligoadenylate synthetase 3 [Source:HGNC Symbol;Acc:HGNC:8088] |
| Ensembl ID | ENSG00000111331 |
| Bio databases IDs | |
| Aliases | 2'-5'-oligoadenylate synthetase 3 |
| Synonyms | 2',5'-OAS, 2'-5'-oligoadenylate synthetase 3, Oasl10, OAS p100, p100, p100OAS |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human OAS3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- 2'-5'-oligoadenylate synthetase 1, domain 2, C-terminus
- Nucleotidyltransferase (NT) domain of DNA polymerase beta and similar proteins
- ATP binding
- double-stranded RNA binding
- enzyme
- protein binding
- 2'-5'-oligoadenylate synthetase
Pathways
Biological processes and signaling networks where the OAS3 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hypertension
- myocardial infarction
- cervical intraepithelial neoplasia
- COVID-19
- diverticular disease of colon
- complete testicular feminization syndrome
- acute myeloid leukemia
- dermatomyositis
- systemic lupus erythematosus
- relapsing-remitting multiple sclerosis
role in cell
- activation in
- apoptosis
- cell death
- degradation in
- growth
- replication in
- synthesis in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- intracellular membrane-bounded organelle
- Plasma Membrane
- cytosol
- nucleoplasm
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human OAS3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of monocyte chemotactic protein-1 production
- MDA-5 signaling pathway
- negative regulation of chemokine (C-X-C motif) ligand 9 production
- negative regulation of type I interferon-mediated signaling pathway
- response to virus
- defense response to bacterium
- nucleobase-containing compound metabolic process
- regulation of ribonuclease activity
- innate immune response
- positive regulation of interferon-beta production
- negative regulation of chemokine (C-C motif) ligand 5 production
- RIG-I signaling pathway
- defense response to virus
- positive regulation of tumor necrosis factor production
- negative regulation of chemokine (C-X-C motif) ligand 2 production
- negative regulation of IP-10 production
- negative regulation of viral genome replication
Cellular Component
Where in the cell the gene product is active
- extracellular space
- cytoplasm
- intracellular membrane-bounded organelle
- membrane
- cytosol
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- 2'-5'-oligoadenylate synthetase activity
- ATP binding
- protein binding
- double-stranded RNA binding
- metal ion binding