Ddn Gene Summary [Rat]
Enables DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within positive regulation of transcription by RNA polymerase II. Located in dendrite. Is active in postsynapse and presynapse. Orthologous to human DDN (dendrin). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ddn |
| Official Name | dendrin [Source:RGD Symbol;Acc:2497] |
| Ensembl ID | ENSRNOG00000059605 |
| Bio databases IDs | |
| Aliases | dendrin |
| Synonyms | Den, Dendrin, Gm748 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ddn often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- Nephrin and CD2AP-binding protein, Dendrin
- transcription regulator
- PPXY motif
- double-stranded DNA binding
- nucleic acid binding
- protein binding
- sequence-specific DNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- pervasive developmental disorder
- schizophrenia
- osteoporosis
- systemic lupus erythematosus
- diabetic nephropathy
- bipolar disorder
- experimental crescentic glomerulonephritis
regulates
- DNA promoter
- DNA endogenous promoter
- caspase 3/7
- RNA polymerase II
role in cell
- apoptosis
- pictilisib sensitivity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- presynaptic regions
- postsynaptic region
- Nucleus
- Plasma Membrane
- intermediate filaments
- dendritic spines
- pedicels
- cellular protrusions
- dendrites
- podocyte slit diaphragm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Ddn gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- nucleus
- cytoplasm
- postsynaptic membrane
- dendritic spine membrane
- perikaryon
- cell projection
Molecular Function
What the gene product does at the molecular level
- protein binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity