Sh3kbp1 Gene Summary [Rat]
Enables ubiquitin protein ligase binding activity. Predicted to be involved in several processes, including actin filament organization; positive regulation of B cell activation; and regulation of cell shape. Is active in GABA-ergic synapse; glutamatergic synapse; and postsynaptic density. Human ortholog(s) of this gene implicated in immunodeficiency 61. Orthologous to human SH3KBP1 (SH3 domain containing kinase binding protein 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Sh3kbp1 |
| Official Name | SH3 domain-containing kinase-binding protein 1 [Source:RGD Symbol;Acc:620904] |
| Ensembl ID | ENSRNOG00000004322 |
| Bio databases IDs | |
| Aliases | SH3 domain-containing kinase-binding protein 1 |
| Synonyms | 1200007H22Rik, 1700125L08Rik, 5830464D22Rik, AGMX2, AI447724, CD2BP3, CIN85, GIG10, HSB-1, IMD61, IN85, MIG18, RUK, Seta, SH3 domain-containing kinase-binding protein 1, SH3-domain kinase binding protein 1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Sh3kbp1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ubiquitin protein ligase binding
- RXXs motif
- coiled-coil domain
- protein binding
- PXXP motif
- proline rich domain
- Src Homology 3 domain superfamily
Pathways
Biological processes and signaling networks where the Sh3kbp1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- prostate cancer
- immunodeficiency type 61
- infiltrating ductal breast carcinoma
- invasive ductal breast cancer
- androgenic alopecia
role in cell
- binding in
- proliferation
- survival
- migration
- expression in
- cell death
- apoptosis
- phosphorylation in
- accumulation in
- activation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- glutaminergic synapse
- postsynaptic region
- cellular membrane
- Plasma Membrane
- endosomes
- intercellular junctions
- cytosol
- perinuclear space
- synaptosomes
- synapse
- late endosomes
- endocytotic vesicle
- postsynaptic density
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Sh3kbp1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of cell shape
- positive regulation of B cell activation
- cytoskeleton organization
- apoptotic process
- cell-cell signaling
- actin filament organization
- endocytosis
- cell migration
Cellular Component
Where in the cell the gene product is active
- endocytic vesicle
- cytoplasmic vesicle membrane
- cytoskeleton
- cell-cell junction
- focal adhesion
- cytoplasm
- cytosol
- synapse
- neuron projection
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- ubiquitin protein ligase binding
- SH3 domain binding