Magi2 Gene Summary [Rat]
Enables kinesin binding activity. A structural constituent of postsynaptic density. Involved in several processes, including nerve growth factor signaling pathway; regulation of neurotransmitter receptor localization to postsynaptic specialization membrane; and regulation of synaptic membrane adhesion. Located in several cellular components, including late endosome; perinuclear region of cytoplasm; and slit diaphragm. Part of protein-containing complex. Is active in GABA-ergic synapse; glutamatergic synapse; and postsynaptic density. Is extrinsic component of postsynaptic membrane. Human ortholog(s) of this gene implicated in nephrotic syndrome type 15. Orthologous to human MAGI2 (membrane associated guanylate kinase, WW and PDZ domain containing 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Magi2 |
| Official Name | membrane associated guanylate kinase, WW and PDZ domain containing 2 [Source:RGD Symbol;Acc:621855] |
| Ensembl ID | ENSRNOG00000013962 |
| Bio databases IDs | |
| Aliases | membrane associated guanylate kinase, WW and PDZ domain containing 2 |
| Synonyms | Acvri1, ACVRINP1, ACVRIP1, AIP-1, ARIP1, membrane associated guanylate kinase, WW and PDZ domain containing 2, mKIAA0705, NPHS15, S-SCAM |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Magi2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Domain present in PSD-95, Dlg, and ZO-1/2
- SMAD binding
- G-protein-coupled receptor binding
- canonical PDZ domain
- enzyme
- protein binding
- receptor binding
- PDZ domain
- WW domain
- kinesin binding
- kinase
- Unstructured region on MAGI
- Domain with 2 conserved Trp (W) residues
- binding protein
- NK
- receptor signaling complex scaffold protein
- WW
- PDZ binding motif
- structural molecule
- cpPDZ_Deg_HtrA-like
- phosphatase binding
Pathways
Biological processes and signaling networks where the Magi2 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-small cell lung cancer
- side effect
- interstitial nephritis
- diabetic nephropathy
- non-insulin-dependent diabetes mellitus
- acute lymphoblastic leukemia
- Huntington disease
- insomnia
- cannabis dependence
- schizophrenia
role in cell
- apoptosis
- phosphorylation in
- proliferation
- migration
- adhesion
- clustering
- morphology
- abnormal morphology
- development
- loss
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- microsomal fraction
- membrane fraction
- glutaminergic synapse
- Cytoplasm
- perinuclear region
- membrane surface
- cellular membrane
- Nucleus
- centriole
- intercellular junctions
- cytosol
- neurites
- synaptosomes
- synapse
- photoreceptor outer segments
- photoreceptor inner segments
- pedicels
- Schmidt-Lanterman incisures
- late endosomes
- tight junctions
- perikaryon
- axons
- dendrites
- postsynaptic density
- podocyte slit diaphragm
- detergent-soluble fraction
- synaptosomal fractions
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Magi2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of receptor internalization
- signal transduction
- negative regulation of cell proliferation
- SMAD protein signal transduction
- nervous system development
- receptor clustering
- clathrin-mediated endocytosis
- planar cell polarity pathway involved in axis elongation
- positive regulation of phosphoprotein phosphatase activity
- glomerular visceral epithelial cell development
- negative regulation of activin receptor signaling pathway
- positive regulation of neuron projection development
- negative regulation of cell migration
- negative regulation of protein kinase B signaling cascade
Cellular Component
Where in the cell the gene product is active
- postsynaptic density
- slit diaphragm
- late endosome
- synapse
- plasma membrane
- photoreceptor outer segment
- dendrite
- nucleus
- tight junction
- centrosome
- perinuclear region of cytoplasm
- cell-cell junction
- centriole
- cytoplasm
- macromolecular complex
- photoreceptor inner segment
Molecular Function
What the gene product does at the molecular level
- phosphatase binding
- protein binding
- SMAD binding
- type II activin receptor binding
- beta-1 adrenergic receptor binding
- receptor signaling complex scaffold activity