Elmo1 Gene Summary [Rat]
Predicted to enable SH3 domain binding activity. Predicted to contribute to guanyl-nucleotide exchange factor activity. Involved in regulation of postsynapse assembly. Is active in glutamatergic synapse and postsynapse. Orthologous to human ELMO1 (engulfment and cell motility 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Elmo1 |
| Official Name | engulfment and cell motility 1 [Source:RGD Symbol;Acc:1308182] |
| Ensembl ID | ENSRNOG00000059705 |
| Bio databases IDs | |
| Aliases | engulfment and cell motility 1 |
| Synonyms | 6330578D22Rik, C230095H21Rik, CED-12, ELMO1s, engulfment and cell motility 1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Elmo1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- alpha helix
- ELMO/CED-12 family
- protein binding
- Pleckstrin homology-like domain
- polyproline motif
- proline rich domain
- SH3-domain binding
- Dock180-binding domain
- ERM binding domain
- ELMO autoregulatory domain
- ELMO, armadillo-like helical domain
- guanyl-nucleotide exchange factor
- Rho-binding domain
- Pleckstrin homology domain
- ELMO inhibitory domain
Pathways
Biological processes and signaling networks where the Elmo1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- liver cancer
- epithelial cancer
- hepatocellular carcinoma
- Alzheimer disease
- autoimmune disease
- systemic sclerosis
- nephrosis
- acute myeloid leukemia
- immunological disorder
- Crohn disease
role in cell
- quantity
- proliferation
- invasion
- activation in
- apoptosis
- accumulation
- migration
- binding in
- transcription in
- abnormal morphology
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- glutaminergic synapse
- postsynaptic region
- Plasma Membrane
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Elmo1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- Rac protein signal transduction
- cell motility
- phagocytosis, engulfment
- apoptotic process
- actin filament organization
- actin cytoskeleton organization
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- membrane
- cytosol
- guanyl-nucleotide exchange factor complex
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- guanyl-nucleotide exchange factor activity
- SH3 domain binding