Gys2 Gene Summary [Rat]
Enables D-glucose binding activity and alpha-1,4-glucan glucosyltransferase (UDP-glucose donor) activity. Involved in glycogen biosynthetic process and response to glucose. Located in cortical actin cytoskeleton and cytosol. Human ortholog(s) of this gene implicated in glycogen storage disease. Orthologous to human GYS2 (glycogen synthase 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Gys2 |
| Official Name | glycogen synthase 2 [Source:RGD Symbol;Acc:2773] |
| Ensembl ID | ENSRNOG00000059753 |
| Bio databases IDs | |
| Aliases | glycogen synthase 2 |
| Synonyms | Glycogen Synthase 2, GLYSN, Gsa, LGS |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Gys2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- glycosyltransferase family 1 and related proteins with GTB topology
- phosphotransferase
- glucose binding
- glycogen(starch) synthase
- enzyme
- protein binding
- Glycogen synthase
Pathways
Biological processes and signaling networks where the Gys2 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hepatocellular carcinoma
- cough
- non-insulin-dependent diabetes mellitus
- ischemic stroke
- eosinophilic esophagitis
- liver cancer
- epithelial cancer
- liver glycogen storage disease type 0
- glycogen storage disease, hepatic form
- glycogen storage disease
regulated by
- streptozocin
- insulin
- D-glucose
- sirolimus
- deoxycholate
- taurocholic acid
- LY294002
- NR3C1
- S 4048
- methapyrilene
role in cell
- activation in
- lipogenesis in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cortical actin cytoskeleton
- cytoskeleton
- cell cortex
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Gys2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- glycogen biosynthetic process
- response to glucose stimulus
Cellular Component
Where in the cell the gene product is active
- cytoskeleton
- cytoplasm
- cell cortex
- cytosol
- cortical actin cytoskeleton
Molecular Function
What the gene product does at the molecular level
- glycogen (starch) synthase activity