Ppp1r3c Gene Summary [Rat]
This gene encodes a carbohydrate binding protein that is a subunit of the protein phosphatase 1 (PP1) complex. PP1 catalyzes reversible protein phosphorylation, which is important in a wide range of cellular activities. The encoded protein affects glycogen biosynthesis by activating glycogen synthase and limiting glycogen breakdown by reducing glycogen phosphorylase activity. DNA hypermethylation of this gene has been found in colorectal cancer patients. The encoded protein also interacts with the laforin protein, which is a protein tyrosine phosphatase implicated in Lafora disease. [provided by RefSeq, Sep 2016]
Details
| Type | Protein Coding |
| Official Symbol | Ppp1r3c |
| Official Name | protein phosphatase 1, regulatory subunit 3C [Source:RGD Symbol;Acc:1309132] |
| Ensembl ID | ENSRNOG00000018494 |
| Bio databases IDs | |
| Aliases | protein phosphatase 1, regulatory subunit 3C |
| Synonyms | LOC100910671, PPP1R5, Ppp1rc, protein PHOSPHATASE 1, Protein phosphatase 1 glycogen targeting subunit, protein phosphatase 1 regulatory subunit 3C, protein phosphatase 1, regulatory subunit 3C, PTG, R5 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ppp1r3c often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Starch/carbohydrate-binding module (family 53)
- Carbohydrate/starch-binding module (family 21)
- protein serine/threonine phosphatase
- protein phosphatase
- protein phosphatase binding
- phosphatase
- enzyme binding
- protein binding
- polysaccharide binding
- [phosphorylase] phosphatase
- PBD_PPP1R3
Pathways
Biological processes and signaling networks where the Ppp1r3c gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- liver cancer
- insulin resistance
- psoriasis
- acute myeloid leukemia
- keratocystic odontogenic tumor
- keratocystic odontogenic tumors
- androgenic alopecia
- autosomal dominant polycystic kidney disease
regulates
- p38 MAPK
- PP1
- SLC2A1
- fatty acid
- triacylglycerol
- D-glucose
- glycogen
- glycogen synthase
- insulin
- ketone
role in cell
- dephosphorylation in
- formation
- quantity
- expression in
- activation in
- accumulation in
- abnormal morphology
- uptake by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Ppp1r3c gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- glycogen biosynthetic process
- glycogen metabolic process
- regulation of glycogen biosynthetic process
Cellular Component
Where in the cell the gene product is active
- protein phosphatase type 1 complex
- cytosol
Molecular Function
What the gene product does at the molecular level
- protein serine/threonine phosphatase activity
- protein phosphatase binding
- protein binding
- protein phosphatase 1 binding
- glycogen binding
- binding, bridging