Gpc3 Gene Summary [Rat]
Predicted to enable peptidyl-dipeptidase inhibitor activity. Acts upstream of or within negative regulation of canonical Wnt signaling pathway and positive regulation of Wnt signaling pathway, planar cell polarity pathway. Located in plasma membrane. Used to study hepatocellular carcinoma. Human ortholog(s) of this gene implicated in Simpson-Golabi-Behmel syndrome type 1 and nephroblastoma. Orthologous to human GPC3 (glypican 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Gpc3 |
| Official Name | glypican 3 [Source:RGD Symbol;Acc:2725] |
| Ensembl ID | ENSRNOG00000060179 |
| Bio databases IDs | |
| Aliases | glypican 3 |
| Synonyms | DGSX, Glypican-3, GTR2-2, MXR7, OCI-5, SDYS, SGB, SGBS, SGBS1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Gpc3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Glypican
- protease inhibitor
- glycosaminoglycan attachment site
- protein binding
- glycan domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- epithelial cancer
- Wilms tumorigenesis
- omphalocele
- hepatitis B virus-related hepatocellular carcinoma
- liver cancer
- polydactyly
- hepatocellular carcinoma
- Simpson-Golabi-Behmel syndrome type 1
- osteosarcoma
role in cell
- migration
- cell death
- number
- colony formation
- apoptosis
- proliferation
- differentiation
- binding
- growth
- survival
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Golgi lumen
- cell surface
- cellular membrane
- lysosome
- endoplasmic reticulum lumen
- lysosomal compartment
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Gpc3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of growth
- positive regulation of endocytosis
- anatomical structure morphogenesis
- anterior/posterior axis specification
- epithelial cell proliferation
- regulation of canonical Wnt receptor signaling pathway
- canonical Wnt receptor signaling pathway
- Wnt receptor signaling pathway, planar cell polarity pathway
- cell proliferation involved in metanephros development
- cell migration
- embryonic hindlimb morphogenesis
- lung development
- regulation of non-canonical Wnt receptor signaling pathway
- bone mineralization
- positive regulation of Wnt receptor signaling pathway, planar cell polarity pathway
- body morphogenesis
- coronary vasculature development
- positive regulation of canonical Wnt receptor signaling pathway
- smoothened signaling pathway
- positive regulation of glucose import
- positive regulation of protein catabolic process
- negative regulation of smoothened signaling pathway
- mesonephric duct morphogenesis
- negative regulation of canonical Wnt receptor signaling pathway
- osteoclast differentiation
- positive regulation of BMP signaling pathway
- response to bacterium
- cell migration involved in gastrulation
- branching involved in ureteric bud morphogenesis
- negative regulation of epithelial cell proliferation
- positive regulation of smoothened signaling pathway
- cell proliferation involved in kidney development
- mesenchymal cell proliferation involved in ureteric bud development
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum lumen
- lysosomal lumen
- Golgi lumen
- plasma membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- protein binding
- peptidyl-dipeptidase inhibitor activity