Atf1 Gene Summary [Rat]
Enables DNA-binding transcription factor activity, RNA polymerase II-specific and sequence-specific DNA binding activity. Involved in several processes, including positive regulation of neuron projection development; positive regulation of nucleobase-containing compound metabolic process; and response to cobalt ion. Part of transcription regulator complex. Biomarker of polycystic kidney disease. Orthologous to human ATF1 (activating transcription factor 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Atf1 |
| Official Name | activating transcription factor 1 [Source:RGD Symbol;Acc:1307360] |
| Ensembl ID | ENSRNOG00000061088 |
| Bio databases IDs | |
| Aliases | activating transcription factor 1 |
| Synonyms | activating transcription factor 1, TREB36 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Atf1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- transcription regulator
- DNA binding domain
- nucleic acid binding
- Basic region leucine zipper
- leucine zipper domain
- protein binding
- sequence-specific DNA binding
- identical protein binding
- DNA binding
- bZIP domain
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- binding protein
- double-stranded DNA binding
- pKID domain
- bZIP
- transcription factor activity
- basic region leucin zipper
Pathways
Biological processes and signaling networks where the Atf1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- colorectal cancer
- sudden cardiac arrest
- colorectal adenoma
- colorectal adenoma formation
- colonic polyp
- side effect
role in cell
- apoptosis
- colony formation
- production in
- growth
- expression in
- cell viability
- invasion
- development
- survival
- cell focus formation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- nucleoplasm
- pronucleus
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Atf1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- macromolecular complex assembly
- response to purine-containing compound
- response to cobalt ion
- positive regulation of DNA replication
- positive regulation of neuron projection development
- positive regulation of transcription from RNA polymerase II promoter
- cAMP-mediated signaling
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- sequence-specific DNA binding transcription factor activity
- protein binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- RNA polymerase II regulatory region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- sequence-specific DNA binding RNA polymerase II transcription factor activity