Fam49b Gene Summary [Rat]
Predicted to enable MHC class Ib protein binding, via antigen binding activity groove and small GTPase binding activity. Predicted to be involved in several processes, including positive regulation of memory T cell activation; positive regulation of type II interferon production; and regulation of organelle organization. Predicted to be located in cilium and mitochondrion. Orthologous to human CYRIB (CYFIP related Rac1 interactor B). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Fam49b |
| Official Name | family with sequence similarity 49, member B [Source:RGD Symbol;Acc:1307697] |
| Ensembl ID | ENSRNOG00000061246 |
| Bio databases IDs | |
| Aliases | family with sequence similarity 49, member B |
| Synonyms | 0910001A06Rik, BM-009, CYFIP related Rac1 interactor B, CYRI, FAM49B, L1, RGD1307697 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Fam49b often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- MHC protein binding
- enzyme binding
- protein binding
- CYRIA/CYRIB Rac1 binding domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- psychoticism
- Parkinson disease
- post-traumatic stress disorder
- rheumatoid arthritis
- male pattern hair loss
- breast cancer
- schizophrenia
- peripheral arterial disease
role in cell
- growth
- expression in
- induction in
- phosphorylation in
- activation
- migration
- cytotoxicity
- phagocytosis by
- invasion by
- transformation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- cilia
- Mitochondria
- alpha granules
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Fam49b gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of T cell activation
- negative regulation of small GTPase mediated signal transduction
- negative regulation of actin filament polymerization
- positive regulation of interferon-gamma production
- regulation of mitochondrial fission
- positive regulation of memory T cell activation
- positive regulation of T cell mediated cytotoxicity
- cellular response to molecule of bacterial origin
- regulation of chemotaxis
- regulation of cell migration
- regulation of establishment of cell polarity
Cellular Component
Where in the cell the gene product is active
- platelet alpha granule lumen
- extracellular vesicular exosome
- membrane
- mitochondrion
- cilium
- extracellular region
Molecular Function
What the gene product does at the molecular level
- protein binding
- MHC class Ib protein binding, via antigen binding groove
- small GTPase binding