Cd69 Gene Summary [Rat]
Enables calcium ion binding activity. Predicted to be involved in cellular response to xenobiotic stimulus; negative regulation of T cell migration; and negative regulation of T-helper 17 cell lineage commitment. Predicted to be located in external side of plasma membrane. Predicted to be part of protein-containing complex. Predicted to be active in plasma membrane. Orthologous to human CD69 (CD69 molecule). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cd69 |
| Official Name | Cd69 molecule [Source:RGD Symbol;Acc:61318] |
| Ensembl ID | ENSRNOG00000056783 |
| Bio databases IDs | |
| Aliases | Cd69 molecule |
| Synonyms | AIM, BL-AC/P26, CD69 ANTIGEN, CD69 molecule, Clec2a, CLEC2C, EA1, GP32/28, MLR-3 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Cd69 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- C-type lectin (CTL)/C-type lectin-like (CTLD) domain
- cytoplasmic domain
- transmembrane domain
- Lectin C-type domain
- calcium ion binding
- protein binding
- identical protein binding
- transmembrane receptor
Pathways
Biological processes and signaling networks where the Cd69 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- breast cancer
- insulin-dependent diabetes mellitus
- peripheral T-cell lymphoma
- T-cell non-Hodgkin disease
- mature T-cell neoplasia
- lung cancer
- celiac disease
- chronic obstructive pulmonary disease
- Devic syndrome
- Sjögren syndrome
role in cell
- expression in
- migration
- proliferation
- production in
- differentiation
- activation in
- apoptosis
- transmembrane potential
- cytotoxicity
- activation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- cellular membrane
- plasma membrane extracellular face
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Cd69 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cellular response to xenobiotic stimulus
Cellular Component
Where in the cell the gene product is active
- external side of plasma membrane
- macromolecular complex
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- transmembrane signaling receptor activity
- protein binding
- carbohydrate binding