GeneGlobe ID: PHS-3000Z | Cat. No.: | QIAseq Targeted DNA Pro Panels

QIAseq Targeted DNA Pro Human Comprehensive Cancer Research Panel

Kit containing ALL reagents (except indexes) for targeted DNA sequencing
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Product Specification

Target List
Brain Cancers
Anaplastic Glial Tumors​
CDKN2A (P16INK4A), CDKN2B (p15INK4b), MDM2, PTEN, RB1, TP53 (p53)
Astrocytomas​
ATRX, BRAF, CHEK2 (RAD53), FGFR1, IDH1, IDH2, KRAS, NOTCH1, PTPN11, RB1, TP53 (p53)
Ependymomas​
CDKN2A (P16INK4A), CDKN2B (p15INK4b), H3-3A, NF2, NOTCH1
Glioblastomas​
ALK, APC, BCOR, BRAF, CDK4, CDK6, CDKN2A (P16INK4A), CDKN2B (p15INK4b), CREBBP (CBP), EGFR (ERBB1), ERBB2 (HER-2, NEU), FGFR3, H3-3A, H3C2, IDH1, IDH2, KIT (CD117), MDM2, MET, MLH1, MSH2, MTOR, MYC, NOTCH1, NRAS, PIK3CA (p110-alpha), PMS2, PTEN, RB1, STK11 (LKB1), TERT, TP53 (p53)
Gliomas​
ACVR1 (ALK2), BRCA2, CHEK2 (RAD53), FGFR1, H3-3A, PDGFRA, PIK3CA (p110-alpha), PTEN, TP53 (p53)
High-Grade Gliomas​
ATRX, BRAF, CIC, EGFR (ERBB1), FUBP1, IDH1, IDH2
Medulloblastomas​
BRCA2, CDK4, CREBBP (CBP), CTNNB1, FGFR1, GLI2, IDH1, IDH2, MSH2, MYC, MYCN, NRAS, PIK3CA (p110-alpha), PTCH2, SMARCA4, SMARCB1, SUFU, TP53 (p53)
Meningiomas​
CDKN2A (P16INK4A), CDKN2B (p15INK4b), NF2, PTEN
Oligodendrogliomas​
IDH1, IDH2, MSH2, NOTCH1, TERT
Breast Cancers
Carcinomas​
ATM, BARD1, BRCA1, BRCA2, BRIP1, CDK12, CDK4, CHEK1, CHEK2 (RAD53), EGFR (ERBB1), ERBB2 (HER-2, NEU), ESR1 (ERα), FANCL, KIT (CD117), KRAS, MET, MLH1, MLH3, MSH2, MSH3, MSH6, PALB2, PDGFRA, PIK3CA (p110-alpha), PMS1, PMS2, RAD51B, RAD51C, RAD51D, RAD54L
Ductal Carcinomas​
AR, CCND1, CDH1 (E-Cadherin), CYP2D6, FANCD2, FBXW7, FGFR1, FGFR2, MRE11, MYC, NBN, NTRK3, PPM1D, PPP2R1A, RB1CC1, SF3B1, SLC22A18, STK11 (LKB1), TP53 (p53)
ER-Positive Carcinomas​
CDH1 (E-Cadherin), RB1CC1, SF3B1
HER-Positive Carcinomas​
AR, CCND1, FANCD2, NTRK3, PPM1D, RB1CC1
Metastatic Breast Cancers​
AKT1, BRCA1, BRCA2, ERBB2 (HER-2, NEU), ERBB3, ESR1 (ERα), MDM2, NF1, PALB2, PIK3CA (p110-alpha), PTEN
Mismatch Repair (MMR) Genes​
MLH1, MSH2, MSH6, PMS2
Colorectal Cancers
Adenocarcinomas​
APC, ARID1A, ATM, AXIN2, BARD1, BAX, BMPR1A (ALK3), BRAF, BRCA1, BRCA2, BRIP1, BUB1, BUB1B, CDK12, CDKN2A (P16INK4A), CHEK1, CHEK2 (RAD53), CTNNB1, DCC, DLC1, EGFR (ERBB1), EP300, ERBB2 (HER-2, NEU), ERBB3, ESR1 (ERα), FANCL, FBXW7, FGFR1, FGFR3, FLCN, GNAS, HRAS, KIT (CD117), KRAS, MAP2K1, MCC, MET, MLH1, MLH3, MSH2, MSH3, MSH6, MUTYH, MYC, NRAS, PALB2, PDGFRA, PDGFRL, PMS1, PMS2, POLD1, POLE, PTEN, PTPN12, PTPRJ, RAD51B, RAD51C, RAD51D, RAD54B, RAD54L, RET, RNF43, SMAD4 (MADH4), SOX9, SRC, STK11 (LKB1), TCF7L2, TGFBR2, TP53 (p53)
Metastatic Colorectal Cancers​
AKT1, ATM, BRAF, ERBB2 (HER-2, NEU), KRAS, MET, NRAS, PIK3CA (p110-alpha)
Mismatch Repair (MMR) Genes​
EPCAM, MLH1, MSH2, MSH6, PMS2
Other Colorectal Cancer Genes​
DPYD, ERCC1, TYMS, UGT1A1
Lung Cancers
Adenocarcinomas​
ABL1, AKT1, ALK, ATM, BRAF, CCND1, CD274 (PD-L1), CD274 (PD-L1), CDK4, CDKN2A (P16INK4A), CTNNB1, DDR2, EGFR (ERBB1), ERBB2 (HER-2, NEU), FGFR1, FGFR3, HRAS, KRAS, MAP2K1, MAP3K8, MET, MYC, MYCN, NRAS, NTRK1, PIK3CA (p110-alpha), PPP2R1B, PRKN, PTEN, RET, ROS1, SLC22A18, STK11 (LKB1), TP53 (p53), TSC2
Malignant Pleural Mesotheliomas​
BAP1, NF2
Non-Small Cell Lung Cancers (NSCLC)​
AKT1, ALK, ATM, BARD1, BRAF, BRCA1, BRCA2, BRIP1, CCND1, CDK12, CDK4, CDKN2A (P16INK4A), CHEK1, CHEK2 (RAD53), CTNNB1, EGFR (ERBB1), ERBB2 (HER-2, NEU), FANCL, FGFR3, HRAS, IDH1, IRF1, KIT (CD117), KRAS, MAP2K1, MET, MLH1, MLH3, MSH2, MSH3, MSH6, MYC, NRAS, PALB2, PDGFRA, PIK3CA (p110-alpha), PMS1, PMS2, PTEN, RAD51B, RAD51C, RAD51D, RAD54L, RET, ROS1, TP53 (p53)
Small Cell Lung Cancers (SCLC)​
CD274 (PD-L1), CD274 (PD-L1), HRAS, MYC, MYCN, NTRK1, PIK3CA (p110-alpha), PPP2R1B, PTEN, RB1, TP53 (p53)
Squamous Cell Carcinomas​
BRAF, CD274 (PD-L1), CD274 (PD-L1), CDKN2A (P16INK4A), DDR2, EGFR (ERBB1), FGFR1, FGFR3, HRAS, MAP3K8, MYC, MYCN, NTRK1, PIK3CA (p110-alpha), PPP2R1B, PTEN, SLC22A18, TP53 (p53), TSC2
Myeloid Neoplasms
Acute Lymphoblastic Leukemia (ALL)​
ABL1, ABL2 (ARG), BIRC3 (c-IAP2), BRAF, BTK, CDKN2A (P16INK4A), CDKN2B (p15INK4b), CREBBP (CBP), CRLF2 (TSLPR), EBF1, EP300, ETV6, FBXW7, FLT3, GATA3, HRAS, IKZF1, IL7R, JAK1, JAK2, JAK3, KDM6A, KMT2A, KRAS, MYC, NOTCH1, NRAS, PAX5, PDGFRB, PLCG2, PTEN, PTPN11, RUNX1 (AML1), SF3B1, SH2B3, TP53 (p53)
Acute Myeloid Leukemia (AML)​
ANKRD26, ASXL1, ATRX, BRCA1, BRCA2, CBFB, CBLB, CBLC, CCND2, CDC25C, CEBPA, CUX1, DCK, DDX41, DHX15, DNMT3A, ELANE, ETV6, FLT3, GATA1, GATA2, GNAS, HRAS, IDH1, IDH2, IKZF1, IKZF2, IKZF3, JAK2, KDM6A, KIT (CD117), KMT2A, KRAS, LUC7L2, MTOR, NPM1, NRAS, NUP214, PDGFRA, PICALM, PRPF8, PTPN11, RB1, RBBP6, RPS14, RUNX1 (AML1), SF3B1, SLC29A1, SMC1A, TERT, TET1, TET2, TP53 (p53), U2AF1, U2AF2, WT1, ZEB2
Acute Promyelocytic Leukemia (APML; APL)​
CEBPA, NPM1, NUMA1, RARA, RUNX1 (AML1)
Atypical Chronic Myeloid Leukemia (aCML)​
ASXL1, CBL, CEBPA, EZH2, FLT3, JAK2, KRAS, NPM1, NRAS, RUNX1 (AML1), SETBP1, SRSF2, TET2, U2AF1
Chronic Lymphocytic Leukemia (CLL)​
ATRX, BCL2, BIRC3 (c-IAP2), BRAF, CBLB, CCND2, CD38, CUX1, GNAS, GNB1, LUC7L2, MYD88, NOTCH1, NRAS, PTPN11, SF3B1, TP53 (p53), U2AF2, XPO1, ZAP70
Chronic Myeloid Leukemia (CML)​
ABL1, ASXL1, BCOR, BCR, BRAF, CBL, CREBBP (CBP), DNMT3A, DNMT3B, EZH2, IDH1, IDH2, IKZF1, JAK2, KRAS, NPM1, NRAS, RUNX1 (AML1), TET1, TET2, TP53 (p53), WT1
Chronic Myelomonocytic Leukemia (CMML)​
ASXL1, BCOR, BCORL1, CBL, CEBPA, DNMT3A, EZH2, FLT3, IDH1, IDH2, JAK2, KIT (CD117), KRAS, MPL, NF1, NPM1, NRAS, PHF6, PTPN11, RUNX1 (AML1), SETBP1, SF3B1, SRSF2, STAG2, TET2, TP53 (p53), U2AF1, ZRSR2
Hairy Cell Leukemia​
BRAF, CDKN1B (P27KIP1), MAP2K1, TP53 (p53)
Juvenile Myelomonocytic Leukemia​
ARHGAP26, CBL, KRAS, NRAS, PTPN11
Acute Lymphocytic Lymphomas​
BIRC3 (c-IAP2), BTK, CDKN2A (P16INK4A), CDKN2B (p15INK4b), MYC, NOTCH1, PLCG2, SF3B1, TP53 (p53)
B Cell Lymphomas​
BCL6, BRAF, CD79A, CHEK2 (RAD53), EZH2, MAP2K1, MYD88, STAT6, TNFRSF14, TP53 (p53)
Burkitt Lymphomas​
CBLB, GNA13, H1-4, MTOR, MYC
Diffuse Large B Cell Lymphomas​
B2M, BCL2, CBLB, GNA13, H1-4, KMT2D, MTOR, PIM1, PRPF8, SOCS1, TNFAIP3
Follicular Lymphomas​
ARID1A, BCL10, BCL2, CARD11, CREBBP (CBP), EP300, EZH2, FOXO1, KMT2D, MEF2B
Mantle Cell Lymphomas​
ATM, CCND1
Marginal Zone Lymphomas​
KLF2, MYD88, NOTCH2, TNFAIP3, TP53 (p53)
Mucosa-Associated Lymphoid Tissue (MALT) Lymphomas​
BCL10, TNFAIP3
Non-Hodgkin Lymphomas​
BRAF, CASP10 (MCH4), NRAS, PIK3CA (p110-alpha), RAD54B, RAD54L, TP53 (p53)
Primary Cutaneous Lymphomas​
CD79B, MYD88
Small Lymphocytic Lymphomas​
ATRX, BCL2, CBLB, CCND2, CUX1, GNAS, LUC7L2, U2AF2, XPO1
T Cell Lymphomas​
ARID1B, ATM, CBLB, CCR4, DNMT3A, IDH1, IDH2, INO80, JAK1, JAK3, RHOA, SETD2, STAT3, STAT5B, TET2
Myelodysplastic Syndromes​
ANKRD26, ASXL1, ATRX, BCOR, BCORL1, CALR, CBL, CEBPA, CSF3R (GM-CSFR), CUX1, DDX41, DKC1, DNMT3A, ETNK1, ETV6, EZH2, FLT3, GATA2, GNAS, GNB1, IDH1, IDH2, JAK2, JAK3, KIT (CD117), KRAS, MPL, NF1, NPM1, NRAS, PHF6, PIGA, PPM1D, PTPN11, RAD21, RUNX1 (AML1), SAMD9, SAMD9L, SETBP1, SF3B1, SMC3, SRP72, SRSF2, STAG2, STAT3, TERC, TERT, TET2, TP53 (p53), U2AF1, WT1, ZRSR2
Myeloproliferative Neoplasms​
ASXL1, BCOR, CALR, CBL, CSF3R (GM-CSFR), DNMT3A, ETV6, EZH2, IDH1, IDH2, JAK2, KIT (CD117), MPL, NOTCH1, NRAS, PDGFRA, RUNX1 (AML1), SETBP1, SF3B1, SH2B3, SRSF2, STAT3, STAT5B, TET2, TP53 (p53), U2AF1, ZRSR2
Essential Thrombocythemia​
ASXL1, CBL, IDH2, JAK2, MPL, SF3B1, TET2, TP53 (p53)
Multiple Myeloma​
ATM, BARD1, BRAF, BRCA1, BRCA2, BRIP1, CHEK1, CHEK2 (RAD53), CXCR4, EGFR (ERBB1), ERBB2 (HER-2, NEU), FANCL, FGFR3, IDH1, IDH2, KIT (CD117), KRAS, MET, NRAS, PALB2, PDGFRA, RAD51B, RAD51C, RAD51D, RET, TP53 (p53)
Plasma Cell Myeloma​
HRAS, MTOR, RB1, SLC29A1
Polycythemia Vera​
ASXL1, DNMT3A, EZH2, IDH1, JAK2, NRAS, TET2, TP53 (p53)
Primary Myelofibrosis​
ASXL1, CBL, DNMT3A, EZH2, IDH1, IDH2, JAK2, MPL, NF1, NRAS, SETBP1, SF3B1, SRSF2, TET2, TP53 (p53)
Systemic Mastocytosis​
ASXL1, CBL, DNMT3A, ETV6, EZH2, IDH2, JAK2, KIT (CD117), KRAS, NPM1, NRAS, RUNX1 (AML1), SETBP1, SF3B1, SRSF2, TET2, TPSAB1, U2AF1
Waldenstrom Macroglobulinemia​
CXCR4, MYD88
Ovarian Cancers
Endometrioid Carcinomas​
CDKN2A (P16INK4A), CTNNB1, FANCF, POLE, PPP2R1A
Epithelial Carcinomas​
ABRAXAS1, ARID1A, ATM, BARD1, BRAF, BRCA1, BRCA2, BRIP1, CCNE1, CDK12, CHEK1, CHEK2 (RAD53), ERBB2 (HER-2, NEU), ERCC1, KRAS, MRE11, NBN, NF1, PALB2, PIK3CA (p110-alpha), PTEN, RAD51B, RAD51C, RAD51D, RB1, TP53 (p53), WT1
Granulosa Cell Tumors​
AKT1, FOXL2
Mixed Adenosquamous Carcinomas​
AKT1, ATR, ATRX, BLM, CCND1, CCND2, CCNE1, CDH1 (E-Cadherin), DICER1, ERBB3, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCI, FANCL, FANCM, FBXW7, FGFR1, FGFR2, FGFR3, KIT (CD117), MYC, OPCML (OBCAM), PDGFRA, PIK3R1 (p85-ALPHA), POLE, PRKN, RAD50, RAD51, RAD52, RAD54L, RB1, RPA1, SMARCA4, STK11 (LKB1)
Mucinous Carcinomas​
ATRX, CDKN2A (P16INK4A), ERBB3, PDGFRA
Serous Carcinomas​
ATR, ATRX, BLM, CCND1, CCND2, CCNE1, CDH1 (E-Cadherin), CDKN2A (P16INK4A), DICER1, ERBB3, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, FANCI, FANCL, FANCM, FBXW7, FGFR1, FGFR2, FGFR3, KIT (CD117), MYC, PPP2R1A, RAD50, RAD51, RAD52, RAD54L, RB1, RPA1, SMARCA4
Mismatch Repair (MMR) Genes​
MLH1, MSH2, MSH6, PMS2
Pancreatic Cancers
Adenocarcinomas​
ATM, CDKN2A (P16INK4A), CFTR, FANCC, FANCG, MLH1, MSH2, MSH6, PALB2, PALLD, PMS2, PRSS1, SMAD4 (MADH4), SPINK1, STK11 (LKB1), TP53 (p53)
Advanced Ductal Adenocarcinomas​
BRAF, BRCA1, BRCA2, ERBB2 (HER-2, NEU), KRAS, MDM2, PIK3CA (p110-alpha)
Ductal Carcinomas​
APC, ARID1A, CDK6, CTNNB1, ERBB3, FBXW7, FGFR1, GNAS, KDM6A, KRAS, MET, MYC, NRAS, PIK3R3, POLE, PREX2, PTCH1, PTEN, RNF43, ROBO2, SLC29A1, SOX9, TCF7L2
Mismatch Repair (MMR) Genes​
MLH1, MSH2, MSH6, PMS2
Prostate Cancers
Adenocarcinomas​
ABRAXAS1, APC, AR, ATR, BARD1, BRAF, BRIP1, CDK12, CHEK1, CHEK2 (RAD53), EPHB2, ERG, ETV1, ETV4, ETV5, FANCA, FANCL, FGFR1, FOXA1, GEN1, HRAS, IDH1, KDM6A, KLF6, KMT2D, KRAS, MAD1L1, MED12, MRE11, MXI1, MYC, NBN, PIK3R1 (p85-ALPHA), PPP2R2A, PTEN, RAD51B, RAD51C, RAD51D, RAD54L, RAF1, RB1, SPOP, TP53 (p53), ZFHX3
Advanced Prostate Cancers​
AKT1, ATM, BRCA1, BRCA2, PALB2, PIK3CA (p110-alpha), PTEN
Ductal Carcinomas​
CTNNB1
Mismatch Repair (MMR) Genes​
MLH1, MSH2, MSH6, PMS2
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