GeneGlobe ID: PHS-3100Z | Cat. No.: | QIAseq Targeted DNA Pro Panels

QIAseq Targeted DNA Pro Human Comprehensive Cancer Focus Panel

Kit containing ALL reagents (except indexes) for targeted DNA sequencing
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Product Specification

Target List
Bladder Cancers
Adenocarcinomas​
KRAS, TP53 (p53)
Transitional Cell Carcinomas​
AKT1, ARID1A, ATM, BRAF, CCND1, CCNE1, CDKN2A (P16INK4A), CTNNB1, ERBB2 (HER-2, NEU), ERBB3, ERCC2 (XPD), FGFR2, FGFR3, HRAS, KDM6A, KRAS, PIK3CA (p110-alpha), PTEN, RB1, TP53 (p53)
Brain Cancers
Anaplastic Glial Tumors​
PTEN, TP53 (p53)
Astrocytomas​
BRAF, CHEK2 (RAD53), FGFR1, IDH1, KRAS, PTPN11, TP53 (p53)
Ependymomas​
H3-3A, NF2
Glioblastomas​
APC, BCOR, BRAF, CREBBP (CBP), EGFR (ERBB1), H3-3A, IDH1, MLH1, MSH2, MTOR, NRAS, PIK3CA (p110-alpha), PMS2, PMS2CL, PTEN, TERT, TP53 (p53)
Gliomas​
ACVR1 (ALK2), BRCA2, CHEK2 (RAD53), FGFR1, H3-3A, PIK3CA (p110-alpha), PTEN, TP53 (p53)
High-Grade Gliomas​
BRAF, EGFR (ERBB1), IDH1
Medulloblastomas​
BRCA2, CREBBP (CBP), FGFR1, IDH1, MSH2, NRAS, PIK3CA (p110-alpha), PTCH2, SUFU, TP53 (p53)
Meningiomas​
NF2, PTEN
Oligodendrogliomas​
IDH1, MSH2, TERT
Breast Cancers
Carcinomas​
ATM, BARD1, BRCA1, BRCA2, BRIP1, CDH1 (E-Cadherin), CDK12, CDK4, CHEK1, CHEK2 (RAD53), EGFR (ERBB1), ERBB2 (HER-2, NEU), ESR1 (ERα), FANCL, FBXW7, KIT (CD117), KRAS, MET, MLH1, MLH3, MSH2, MSH3, MSH6, PALB2, PDGFRA, PIK3CA (p110-alpha), PMS1, PMS2, RAD51B, RAD51C, RAD51D, RAD54L, SF3B1
Metastatic Breast Cancers​
AKT1, BRCA1, BRCA2, ERBB2 (HER-2, NEU), ERBB3, ESR1 (ERα), PALB2, PIK3CA (p110-alpha), PTEN
Mismatch Repair (MMR) Genes​
MLH1, MSH2, MSH6, PMS2
Colorectal Cancers
Adenocarcinomas​
APC, ARID1A, ATM, BARD1, BRAF, BRCA1, BRCA2, BRIP1, CDK12, CDKN2A (P16INK4A), CHEK1, CHEK2 (RAD53), CTNNB1, EGFR (ERBB1), ERBB2 (HER-2, NEU), ERBB3, FANCL, FBXW7, GNAS, KIT (CD117), KRAS, MAP2K1, MET, MLH1, MLH3, MSH2, MSH3, MSH6, MYC, NRAS, PALB2, PDGFRA, PMS1, PMS2, PMS2CL, POLE, PTEN, RAD51B, RAD51C, RAD51D, RAD54L, RET, RNF43, SMAD4 (MADH4), TCF7L2, TGFBR2, TP53 (p53)
Metastatic Colorectal Cancers​
AKT1, ATM, BRAF, ERBB2 (HER-2, NEU), KRAS, MET, NRAS, PIK3CA (p110-alpha)
Mismatch Repair (MMR) Genes​
MLH1, MSH2, MSH6, PMS2, PMS2CL
Other Colorectal Cancer Genes​
DPYD, ERCC1, TYMS, UGT1A1
Gastric Cancers
Adenocarcinomas​
APC, ARID1A, CDKN2A (P16INK4A), CTNNB1, ERBB2 (HER-2, NEU), ERBB3, FBXW7, GNAS, KMT2D, KRAS, MYC, PIK3CA (p110-alpha), PTEN, RNF43, SMAD4 (MADH4), TP53 (p53)
Adenomas​
APC, CTNNB1, GNAS, KRAS
Gastrointestinal Stromal Tumors (GIST)​
BRAF, KIT (CD117), PDGFRA
Other Gastric Cancer Genes​
CDH1 (E-Cadherin), MET
Liver Cancers
Advanced Cholangiocarcinomas​
BRAF, IDH1
Hepatoblastomas​
CTNNB1, TP53 (p53)
Hepatocellular Carcinomas​
ALB, APC, APOB, ARID1A, ARID2, AXIN1, CCND1, CDKN2A (P16INK4A), CREBBP (CBP), CTNNB1, IDH1, IDH2, JAK1, KEAP1, KRAS, MYC, NFE2L2, NRAS, PIK3CA (p110-alpha), RB1, RIT1, TERT, TP53 (p53), TSC2
Lung Cancers
Adenocarcinomas​
ABL1, ALK, ATM, BRAF, CDK4, CDKN2A (P16INK4A), CTNNB1, EGFR (ERBB1), ERBB2 (HER-2, NEU), KRAS, MAP2K1, MET, NRAS, NTRK1, PIK3CA (p110-alpha), PTEN, RET, ROS1, TP53 (p53), TSC2
Malignant Pleural Mesotheliomas​
NF2
Non-Small Cell Lung Cancers (NSCLC)​
ALK, ATM, BARD1, BRAF, BRCA1, BRCA2, BRIP1, CDK12, CDK4, CDKN2A (P16INK4A), CHEK1, CHEK2 (RAD53), CTNNB1, EGFR (ERBB1), ERBB2 (HER-2, NEU), FANCL, KIT (CD117), KRAS, MAP2K1, MET, MLH1, MLH3, MSH2, MSH3, MSH6, NRAS, PALB2, PDGFRA, PIK3CA (p110-alpha), PMS1, PMS2, PTEN, RAD51B, RAD51C, RAD51D, RAD54L, RET, ROS1, TP53 (p53)
Small Cell Lung Cancers (SCLC)​
NTRK1, PIK3CA (p110-alpha), PTEN, RB1, TP53 (p53)
Squamous Cell Carcinomas​
BRAF, CDKN2A (P16INK4A), EGFR (ERBB1), NTRK1, PIK3CA (p110-alpha), PTEN, TP53 (p53), TSC2
Melanomas
Cutaneous Melanomas​
KRAS, MLH1, MLH3, MSH2, MSH6, NRAS
Malignant Melanomas​
AKT3, ARID2, BRAF, CCND1, CDK4, CDKN2A (P16INK4A), CREBBP (CBP), CTNNB1, ERBB4, EZH2, GNA11, GNAQ, GRIN2A, HRAS, IDH1, KIT (CD117), KRAS, MAP2K1, MAP2K2 (MEK2), MITF, NF1, NRAS, PIK3CA (p110-alpha), PPP6C, PTEN, RAC1, RAF1, RB1, TERT, TP53 (p53)
Mucosal Melanomas​
BRAF, KIT (CD117), MLH1, MLH3, MSH2, MSH6, NRAS
Ocular Melanomas​
MLH1, MLH3, MSH2, MSH6
Uveal Melanomas​
ATM, BAP1, BRCA1, BRCA2, CDK12, EGFR (ERBB1), FANCL, KRAS, MLH1, MLH3, MSH2, MSH6, NRAS, PALB2, PLCB4
Other Melanoma Genes​
BARD1, BRIP1, CHEK1, CHEK2 (RAD53), PDGFRA, RAD51B, RAD51C, RAD51D
Myeloid Neoplasms
Acute Lymphoblastic Leukemia (ALL)​
ABL1, BRAF, BTK, CDKN2A (P16INK4A), CREBBP (CBP), ETV6, FBXW7, FLT3, HRAS, JAK1, JAK2, JAK3, KMT2A, KRAS, MYC, NOTCH1, NRAS, PTEN, PTPN11, RUNX1 (AML1), SF3B1, TP53 (p53)
Acute Myeloid Leukemia (AML)​
ASXL1, ATRX, BRCA1, BRCA2, CBLB, CBLC, CEBPA, DNMT3A, ETV6, FLT3, GATA1, GATA2, GNAS, HRAS, IDH1, IDH2, JAK2, KIT (CD117), KMT2A, KRAS, MTOR, NPM1, NRAS, PDGFRA, PTPN11, RUNX1 (AML1), SF3B1, SMC1A, TET2, TP53 (p53), U2AF1, WT1
Acute Promyelocytic Leukemia (APML; APL)​
CEBPA, NPM1, RUNX1 (AML1)
Atypical Chronic Myeloid Leukemia (aCML)​
ASXL1, CBL, CEBPA, EZH2, FLT3, JAK2, KRAS, NPM1, NRAS, RUNX1 (AML1), SETBP1, SRSF2, TET2, U2AF1
Chronic Lymphocytic Leukemia (CLL)​
ATRX, BCL2, BRAF, CBLB, GNAS, GNB1, MYD88, NOTCH1, NRAS, PTPN11, SF3B1, TP53 (p53), XPO1
Chronic Myeloid Leukemia (CML)​
ABL1, ASXL1, BCOR, BRAF, CBL, CREBBP (CBP), DNMT3A, EZH2, IDH1, IDH2, JAK2, KRAS, NPM1, NRAS, RUNX1 (AML1), TET2, TP53 (p53), WT1
Chronic Myelomonocytic Leukemia (CMML)​
ASXL1, BCOR, BCORL1, CBL, CEBPA, DNMT3A, EZH2, FLT3, IDH1, IDH2, JAK2, KIT (CD117), KRAS, MPL, NF1, NPM1, NRAS, PHF6, PTPN11, RUNX1 (AML1), SETBP1, SF3B1, SRSF2, STAG2, TET2, TP53 (p53), U2AF1, ZRSR2
Hairy Cell Leukemia​
BRAF, TP53 (p53)
Juvenile Myelomonocytic Leukemia​
CBL, KRAS, NRAS, PTPN11
Acute Lymphocytic Lymphomas​
BTK, CDKN2A (P16INK4A), MYC, NOTCH1, SF3B1, TP53 (p53)
B Cell Lymphomas​
BCL6, BRAF, CHEK2 (RAD53), EZH2, MYD88, TP53 (p53)
Burkitt Lymphomas​
CBLB, GNA13, MTOR, MYC
Diffuse Large B Cell Lymphomas​
B2M, BCL2, CBLB, GNA13, KMT2D, MTOR, PIM1, SOCS1, TNFAIP3
Follicular Lymphomas​
ARID1A, BCL2, CARD11, CREBBP (CBP), EZH2, KMT2D
Mantle Cell Lymphomas​
ATM
Marginal Zone Lymphomas​
MYD88, TNFAIP3, TP53 (p53)
Mucosa-Associated Lymphoid Tissue (MALT) Lymphomas​
TNFAIP3
Non-Hodgkin Lymphomas​
BRAF, NRAS, PIK3CA (p110-alpha), TP53 (p53)
Primary Cutaneous Lymphomas​
CD79B, MYD88
Small Lymphocytic Lymphomas​
ATRX, BCL2, CBLB, GNAS, XPO1
T Cell Lymphomas​
ATM, CBLB, DNMT3A, IDH1, IDH2, JAK1, JAK3, RHOA, STAT3, STAT5B, TET2
Myelodysplastic Syndromes​
ASXL1, ATRX, BCOR, BCORL1, CALR, CBL, CEBPA, CSF3R (GM-CSFR), DNMT3A, ETV6, EZH2, FLT3, GATA2, GNAS, GNB1, IDH1, IDH2, JAK2, JAK3, KIT (CD117), KRAS, MPL, NF1, NPM1, NRAS, PHF6, PPM1D, PTPN11, RAD21, RUNX1 (AML1), SETBP1, SF3B1, SMC3, SRSF2, STAG2, STAT3, TET2, TP53 (p53), U2AF1, WT1, ZRSR2
Myeloproliferative Neoplasms​
ASXL1, CALR, CBL, DNMT3A, EZH2, IDH1, IDH2, JAK2, MPL, RUNX1 (AML1), SF3B1, SRSF2, TP53 (p53), U2AF1
Essential Thrombocythemia​
ASXL1, CBL, IDH2, JAK2, MPL, SF3B1, TET2, TP53 (p53)
Multiple Myeloma​
ATM, BARD1, BRAF, BRCA1, BRCA2, BRIP1, CHEK1, CHEK2 (RAD53), EGFR (ERBB1), ERBB2 (HER-2, NEU), FANCL, FGFR3, IDH1, IDH2, KIT (CD117), KRAS, MET, NRAS, PALB2, PDGFRA, RAD51B, RAD51C, RAD51D, RET, TP53 (p53)
Plasma Cell Myeloma​
HRAS, MTOR
Polycythemia Vera​
ASXL1, DNMT3A, EZH2, IDH1, JAK2, NRAS, TET2, TP53 (p53)
Primary Myelofibrosis​
ASXL1, CBL, DNMT3A, EZH2, IDH1, IDH2, JAK2, MPL, NF1, NRAS, SETBP1, SF3B1, SRSF2, TET2, TP53 (p53)
Systemic Mastocytosis​
ASXL1, CBL, DNMT3A, ETV6, EZH2, IDH2, JAK2, KIT (CD117), KRAS, NPM1, NRAS, RUNX1 (AML1), SETBP1, SF3B1, SRSF2, TET2, U2AF1
Waldenstrom Macroglobulinemia​
MYD88
Ovarian Cancers
Endometrioid Carcinomas​
CTNNB1, POLE, PPP2R1A
Epithelial Carcinomas​
ARID1A, BRCA1, BRCA2, CCNE1, CHEK2 (RAD53), ERBB2 (HER-2, NEU), KRAS, PIK3CA (p110-alpha), PTEN, RB1, TP53 (p53)
Granulosa Cell Tumors​
AKT1, FOXL2
Mixed Adenosquamous Carcinomas​
AKT1, CCNE1, ERBB3, FANCM, FBXW7, FGFR2, MYC, PIK3R1 (p85-ALPHA), POLE, RB1, STK11 (LKB1)
Mucinous Carcinomas​
ERBB3
Serous Carcinomas​
CCNE1, ERBB3, FANCM, FBXW7, FGFR2, MYC, PPP2R1A, RB1
Pancreatic Cancers
Adenocarcinomas​
CDKN2A (P16INK4A), MSH6, PMS2, SMAD4 (MADH4), TP53 (p53)
Advanced Ductal Adenocarcinomas​
BRAF, BRCA1, BRCA2, ERBB2 (HER-2, NEU), KRAS, PIK3CA (p110-alpha)
Ductal Carcinomas​
APC, ARID1A, CTNNB1, ERBB3, FBXW7, GNAS, MYC, NRAS, POLE, PTEN, RNF43, TCF7L2
Mismatch Repair (MMR) Genes​
MSH6, PMS2
Prostate Cancers
Adenocarcinomas​
APC, AR, BRAF, CHEK2 (RAD53), FOXA1, HRAS, IDH1, KDM6A, KMT2D, KRAS, MED12, MYC, PIK3R1 (p85-ALPHA), PTEN, RB1, SPOP, TP53 (p53)
Advanced Prostate Cancers​
AKT1, BRCA2, PIK3CA (p110-alpha), PTEN
Ductal Carcinomas​
CTNNB1
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