Target List
Covers specific hotspots of the targeted genes based on the Human GRCh38 genome build
Bladder Cancers
Adenocarcinomas
KRASTP53 (p53)
Transitional Cell Carcinomas
AKT1ARID1AATMBRAFCCND1CCNE1CDKN2A (P16INK4A)CTNNB1ERBB2 (HER-2, NEU)ERBB3ERCC2 (XPD)FGFR2FGFR3HRASKDM6AKRASPIK3CA (p110-alpha)PTENRB1TP53 (p53)
Brain Cancers
Anaplastic Glial Tumors
PTENTP53 (p53)
Astrocytomas
BRAFCHEK2 (RAD53)FGFR1IDH1KRASPTPN11TP53 (p53)
Ependymomas
H3-3ANF2
Glioblastomas
APCBCORBRAFCREBBP (CBP)EGFR (ERBB1)H3-3AIDH1MLH1MSH2MTORNRASPIK3CA (p110-alpha)PMS2PMS2CLPTENTERTTP53 (p53)
Gliomas
ACVR1 (ALK2)BRCA2CHEK2 (RAD53)FGFR1H3-3APIK3CA (p110-alpha)PTENTP53 (p53)
High-Grade Gliomas
BRAFEGFR (ERBB1)IDH1
Medulloblastomas
BRCA2CREBBP (CBP)FGFR1IDH1MSH2NRASPIK3CA (p110-alpha)PTCH2SUFUTP53 (p53)
Meningiomas
NF2PTEN
Oligodendrogliomas
IDH1MSH2TERT
Breast Cancers
Carcinomas
ATMBARD1BRCA1BRCA2BRIP1CDH1 (E-Cadherin)CDK12CDK4CHEK1CHEK2 (RAD53)EGFR (ERBB1)ERBB2 (HER-2, NEU)ESR1 (ERα)FANCLFBXW7KIT (CD117)KRASMETMLH1MLH3MSH2MSH3MSH6PALB2PDGFRAPIK3CA (p110-alpha)PMS1PMS2RAD51BRAD51CRAD51DRAD54LSF3B1
Metastatic Breast Cancers
AKT1BRCA1BRCA2ERBB2 (HER-2, NEU)ERBB3ESR1 (ERα)PALB2PIK3CA (p110-alpha)PTEN
Mismatch Repair (MMR) Genes
MLH1MSH2MSH6PMS2
Colorectal Cancers
Adenocarcinomas
APCARID1AATMBARD1BRAFBRCA1BRCA2BRIP1CDK12CDKN2A (P16INK4A)CHEK1CHEK2 (RAD53)CTNNB1EGFR (ERBB1)ERBB2 (HER-2, NEU)ERBB3FANCLFBXW7GNASKIT (CD117)KRASMAP2K1METMLH1MLH3MSH2MSH3MSH6MYCNRASPALB2PDGFRAPMS1PMS2PMS2CLPOLEPTENRAD51BRAD51CRAD51DRAD54LRETRNF43SMAD4 (MADH4)TCF7L2TGFBR2TP53 (p53)
Metastatic Colorectal Cancers
AKT1ATMBRAFERBB2 (HER-2, NEU)KRASMETNRASPIK3CA (p110-alpha)
Mismatch Repair (MMR) Genes
MLH1MSH2MSH6PMS2PMS2CL
Other Colorectal Cancer Genes
DPYDERCC1TYMSUGT1A1
Gastric Cancers
Adenocarcinomas
APCARID1ACDKN2A (P16INK4A)CTNNB1ERBB2 (HER-2, NEU)ERBB3FBXW7GNASKMT2DKRASMYCPIK3CA (p110-alpha)PTENRNF43SMAD4 (MADH4)TP53 (p53)
Adenomas
APCCTNNB1GNASKRAS
Gastrointestinal Stromal Tumors (GIST)
BRAFKIT (CD117)PDGFRA
Other Gastric Cancer Genes
CDH1 (E-Cadherin)MET
Liver Cancers
Advanced Cholangiocarcinomas
BRAFIDH1
Hepatoblastomas
CTNNB1TP53 (p53)
Hepatocellular Carcinomas
ALBAPCAPOBARID1AARID2AXIN1CCND1CDKN2A (P16INK4A)CREBBP (CBP)CTNNB1IDH1IDH2JAK1KEAP1KRASMYCNFE2L2NRASPIK3CA (p110-alpha)RB1RIT1TERTTP53 (p53)TSC2
Lung Cancers
Adenocarcinomas
ABL1ALKATMBRAFCDK4CDKN2A (P16INK4A)CTNNB1EGFR (ERBB1)ERBB2 (HER-2, NEU)KRASMAP2K1METNRASNTRK1PIK3CA (p110-alpha)PTENRETROS1TP53 (p53)TSC2
Malignant Pleural Mesotheliomas
NF2
Non-Small Cell Lung Cancers (NSCLC)
ALKATMBARD1BRAFBRCA1BRCA2BRIP1CDK12CDK4CDKN2A (P16INK4A)CHEK1CHEK2 (RAD53)CTNNB1EGFR (ERBB1)ERBB2 (HER-2, NEU)FANCLKIT (CD117)KRASMAP2K1METMLH1MLH3MSH2MSH3MSH6NRASPALB2PDGFRAPIK3CA (p110-alpha)PMS1PMS2PTENRAD51BRAD51CRAD51DRAD54LRETROS1TP53 (p53)
Small Cell Lung Cancers (SCLC)
NTRK1PIK3CA (p110-alpha)PTENRB1TP53 (p53)
Squamous Cell Carcinomas
BRAFCDKN2A (P16INK4A)EGFR (ERBB1)NTRK1PIK3CA (p110-alpha)PTENTP53 (p53)TSC2
Melanomas
Cutaneous Melanomas
KRASMLH1MLH3MSH2MSH6NRAS
Malignant Melanomas
AKT3ARID2BRAFCCND1CDK4CDKN2A (P16INK4A)CREBBP (CBP)CTNNB1ERBB4EZH2GNA11GNAQGRIN2AHRASIDH1KIT (CD117)KRASMAP2K1MAP2K2 (MEK2)MITFNF1NRASPIK3CA (p110-alpha)PPP6CPTENRAC1RAF1RB1TERTTP53 (p53)
Mucosal Melanomas
BRAFKIT (CD117)MLH1MLH3MSH2MSH6NRAS
Ocular Melanomas
MLH1MLH3MSH2MSH6
Uveal Melanomas
ATMBAP1BRCA1BRCA2CDK12EGFR (ERBB1)FANCLKRASMLH1MLH3MSH2MSH6NRASPALB2PLCB4
Other Melanoma Genes
BARD1BRIP1CHEK1CHEK2 (RAD53)PDGFRARAD51BRAD51CRAD51D
Myeloid Neoplasms
Acute Lymphoblastic Leukemia (ALL)
ABL1BRAFBTKCDKN2A (P16INK4A)CREBBP (CBP)ETV6FBXW7FLT3HRASJAK1JAK2JAK3KMT2AKRASMYCNOTCH1NRASPTENPTPN11RUNX1 (AML1)SF3B1TP53 (p53)
Acute Myeloid Leukemia (AML)
ASXL1ATRXBRCA1BRCA2CBLBCBLCCEBPADNMT3AETV6FLT3GATA1GATA2GNASHRASIDH1IDH2JAK2KIT (CD117)KMT2AKRASMTORNPM1NRASPDGFRAPTPN11RUNX1 (AML1)SF3B1SMC1ATET2TP53 (p53)U2AF1WT1
Acute Promyelocytic Leukemia (APML; APL)
CEBPANPM1RUNX1 (AML1)
Atypical Chronic Myeloid Leukemia (aCML)
ASXL1CBLCEBPAEZH2FLT3JAK2KRASNPM1NRASRUNX1 (AML1)SETBP1SRSF2TET2U2AF1
Chronic Lymphocytic Leukemia (CLL)
ATRXBCL2BRAFCBLBGNASGNB1MYD88NOTCH1NRASPTPN11SF3B1TP53 (p53)XPO1
Chronic Myeloid Leukemia (CML)
ABL1ASXL1BCORBRAFCBLCREBBP (CBP)DNMT3AEZH2IDH1IDH2JAK2KRASNPM1NRASRUNX1 (AML1)TET2TP53 (p53)WT1
Chronic Myelomonocytic Leukemia (CMML)
ASXL1BCORBCORL1CBLCEBPADNMT3AEZH2FLT3IDH1IDH2JAK2KIT (CD117)KRASMPLNF1NPM1NRASPHF6PTPN11RUNX1 (AML1)SETBP1SF3B1SRSF2STAG2TET2TP53 (p53)U2AF1ZRSR2
Hairy Cell Leukemia
BRAFTP53 (p53)
Juvenile Myelomonocytic Leukemia
CBLKRASNRASPTPN11
Acute Lymphocytic Lymphomas
BTKCDKN2A (P16INK4A)MYCNOTCH1SF3B1TP53 (p53)
B Cell Lymphomas
BCL6BRAFCHEK2 (RAD53)EZH2MYD88TP53 (p53)
Burkitt Lymphomas
CBLBGNA13MTORMYC
Diffuse Large B Cell Lymphomas
B2MBCL2CBLBGNA13KMT2DMTORPIM1SOCS1TNFAIP3
Follicular Lymphomas
ARID1ABCL2CARD11CREBBP (CBP)EZH2KMT2D
Mantle Cell Lymphomas
ATM
Marginal Zone Lymphomas
MYD88TNFAIP3TP53 (p53)
Mucosa-Associated Lymphoid Tissue (MALT) Lymphomas
TNFAIP3
Non-Hodgkin Lymphomas
BRAFNRASPIK3CA (p110-alpha)TP53 (p53)
Primary Cutaneous Lymphomas
CD79BMYD88
Small Lymphocytic Lymphomas
ATRXBCL2CBLBGNASXPO1
T Cell Lymphomas
ATMCBLBDNMT3AIDH1IDH2JAK1JAK3RHOASTAT3STAT5BTET2
Myelodysplastic Syndromes
ASXL1ATRXBCORBCORL1CALRCBLCEBPACSF3R (GM-CSFR)DNMT3AETV6EZH2FLT3GATA2GNASGNB1IDH1IDH2JAK2JAK3KIT (CD117)KRASMPLNF1NPM1NRASPHF6PPM1DPTPN11RAD21RUNX1 (AML1)SETBP1SF3B1SMC3SRSF2STAG2STAT3TET2TP53 (p53)U2AF1WT1ZRSR2
Myeloproliferative Neoplasms
ASXL1CALRCBLDNMT3AEZH2IDH1IDH2JAK2MPLRUNX1 (AML1)SF3B1SRSF2TP53 (p53)U2AF1
Essential Thrombocythemia
ASXL1CBLIDH2JAK2MPLSF3B1TET2TP53 (p53)
Multiple Myeloma
ATMBARD1BRAFBRCA1BRCA2BRIP1CHEK1CHEK2 (RAD53)EGFR (ERBB1)ERBB2 (HER-2, NEU)FANCLFGFR3IDH1IDH2KIT (CD117)KRASMETNRASPALB2PDGFRARAD51BRAD51CRAD51DRETTP53 (p53)
Plasma Cell Myeloma
HRASMTOR
Polycythemia Vera
ASXL1DNMT3AEZH2IDH1JAK2NRASTET2TP53 (p53)
Primary Myelofibrosis
ASXL1CBLDNMT3AEZH2IDH1IDH2JAK2MPLNF1NRASSETBP1SF3B1SRSF2TET2TP53 (p53)
Systemic Mastocytosis
ASXL1CBLDNMT3AETV6EZH2IDH2JAK2KIT (CD117)KRASNPM1NRASRUNX1 (AML1)SETBP1SF3B1SRSF2TET2U2AF1
Waldenstrom Macroglobulinemia
MYD88
Ovarian Cancers
Endometrioid Carcinomas
CTNNB1POLEPPP2R1A
Epithelial Carcinomas
ARID1ABRCA1BRCA2CCNE1CHEK2 (RAD53)ERBB2 (HER-2, NEU)KRASPIK3CA (p110-alpha)PTENRB1TP53 (p53)
Granulosa Cell Tumors
AKT1FOXL2
Mixed Adenosquamous Carcinomas
AKT1CCNE1ERBB3FANCMFBXW7FGFR2MYCPIK3R1 (p85-ALPHA)POLERB1STK11 (LKB1)
Mucinous Carcinomas
ERBB3
Serous Carcinomas
CCNE1ERBB3FANCMFBXW7FGFR2MYCPPP2R1ARB1
Pancreatic Cancers
Adenocarcinomas
CDKN2A (P16INK4A)MSH6PMS2SMAD4 (MADH4)TP53 (p53)
Advanced Ductal Adenocarcinomas
BRAFBRCA1BRCA2ERBB2 (HER-2, NEU)KRASPIK3CA (p110-alpha)
Ductal Carcinomas
APCARID1ACTNNB1ERBB3FBXW7GNASMYCNRASPOLEPTENRNF43TCF7L2
Mismatch Repair (MMR) Genes
MSH6PMS2
Prostate Cancers
Adenocarcinomas
APCARBRAFCHEK2 (RAD53)FOXA1HRASIDH1KDM6AKMT2DKRASMED12MYCPIK3R1 (p85-ALPHA)PTENRB1SPOPTP53 (p53)
Advanced Prostate Cancers
AKT1BRCA2PIK3CA (p110-alpha)PTEN
Ductal Carcinomas
CTNNB1