TET3 Gene Summary
Enables methyl-CpG binding activity and zinc ion binding activity. Involved in histone H3-K4 trimethylation; positive regulation of transcription by RNA polymerase II; and protein O-linked glycosylation. Predicted to be located in cytoplasm and male pronucleus. Predicted to be active in nucleus. Biomarker of esophagus squamous cell carcinoma. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | TET3 |
| Official Name | tet methylcytosine dioxygenase 3 [Source:HGNC Symbol;Acc:HGNC:28313] |
| Ensembl ID | ENSG00000187605 |
| Bio databases IDs | |
| Aliases | tet methylcytosine dioxygenase 3, ten-eleven translocation 3 |
| Synonyms | B430006D22Rik,BEFAHRS,D230004J03Rik,hCG 40738,LOC102550055,LOC107985899,LOC232158,LOC680588,RGD1561966,RP11 287D14,tet methylcytosine dioxygenase 3 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- zinc ion binding
- catalytic domain
- double-stranded DNA binding
- nucleic acid binding
- methyl-CpG binding
- 2-oxoglutarate:oxygen oxidoreductase
- enzyme
- protein binding
- CXXC zinc finger domain
- sequence-specific DNA binding
Pathways
Biological processes and signaling networks where the TET3 gene plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- plasma cell myeloma
- systemic lupus erythematosus
- obesity
- chronic kidney disease
- hypertension
- diabetes mellitus
- rheumatoid arthritis
- organismal death
- liver cancer
role in cell
- cell viability
- expression in
- invasion by
- migration
- activation in
- number
- apoptosis
- G2/M phase
- upregulation in
- proliferation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- nucleoplasm
- pronucleus
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the TET3 gene, providing context for its role in the cell.
biological PROCESS
Functions and activities the gene product is involved in
- protein O-linked glycosylation
- 5-methylcytosine catabolic process
- hypomethylation of CpG island
- positive regulation of transcription from RNA polymerase II promoter
cellular COMPONENT
Where in the cell the gene product is active
- nucleus
- male pronucleus
- cytoplasm
- chromosome
- female pronucleus
molecular FUNCTION
What the gene product does at the molecular level
- zinc ion binding
- protein binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- methyl-CpG binding
- methylcytosine dioxygenase activity