EXOSC4 Gene Summary [Human]
Enables mRNA 3'-UTR AU-rich region binding activity. Involved in nucleic acid metabolic process and positive regulation of cell growth. Acts upstream of or within defense response to virus. Located in cytosol; nucleoplasm; and transcriptionally active chromatin. Part of exosome (RNase complex). [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | EXOSC4 |
| Official Name | exosome component 4 [Source:HGNC Symbol;Acc:HGNC:18189] |
| Ensembl ID | ENSG00000178896 |
| Bio databases IDs | |
| Aliases | exosome component 4, exosome component Rrp41 |
| Synonyms | 1110039I09Rik, 1500001N04Rik, Exosome component 4, hRrp41p, p12A, RRP41, RRP41A, Rrp41p, SKI6, Ski6p |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human EXOSC4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- 3' exoribonuclease family, domain 2
- RNase PH-like 3'-5' exoribonucleases
- mRNA 3' UTR binding
- protein binding
- 3' exoribonuclease family, domain 1
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- intracellular membrane-bounded organelle
- Cytoplasm
- cytosol
- nucleoplasm
- nucleoli
- chromatin
- exosomes
- cytoplasmic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human EXOSC4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- U4 snRNA 3'-end processing
- nuclear-transcribed mRNA catabolic process
- DNA deamination
- RNA processing
- rRNA processing
- RNA catabolic process
- polyadenylation-dependent snoRNA 3'-end processing
- positive regulation of cell growth
- maturation of 5.8S rRNA
- histone mRNA catabolic process
- rRNA catabolic process
- nuclear mRNA surveillance
- defense response to virus
Cellular Component
Where in the cell the gene product is active
- cytoplasmic exosome (RNase complex)
- nucleus
- nuclear exosome (RNase complex)
- euchromatin
- cytoplasm
- intracellular membrane-bounded organelle
- cytosol
- nucleolus
- nucleoplasm
- exosome (RNase complex)
Molecular Function
What the gene product does at the molecular level
- 3'-5'-exoribonuclease activity
- RNA binding
- protein binding
- mRNA 3'-UTR AU-rich region binding
- exoribonuclease activity