DPY30 Gene Summary [Human]
This gene encodes an integral core subunit of the SET1/MLL family of H3K4 methyltransferases. The encoded protein directly controls cell cycle regulators and plays an important role in the proliferation and differentiation of human hematopoietic progenitor cells. [provided by RefSeq, Mar 2016]
Details
| Type | Processed Transcript |
| Official Symbol | DPY30 |
| Official Name | dpy-30 histone methyltransferase complex regulatory subunit [Source:HGNC Symbol;Acc:HGNC:24590] |
| Ensembl ID | ENSG00000162961 |
| Bio databases IDs | |
| Aliases | dpy-30 histone methyltransferase complex regulatory subunit |
| Synonyms | 2810410M20Rik, Aip1, Cps25, dpy-30 histone methyltransferase complex regulatory subunit, dpy-30, histone methyltransferase complex regulatory subunit, DPY-30-LIKE, HDPY-30, Saf19 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human DPY30 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein homodimerization
- protein binding
- DD_R_PKA_DPY30-like
- identical protein binding
- Dpy-30 motif
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
role in cell
- formation in
- expression in
- formation
- proliferation
- migration
- binding in
- senescence
- cell-matrix adhesion
- morphology
- transport
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Golgi Apparatus
- trans Golgi network
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human DPY30 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of gene expression, epigenetic
- endosomal transport
Cellular Component
Where in the cell the gene product is active
- Set1C/COMPASS complex
- nucleus
- trans-Golgi network
- histone methyltransferase complex
- Golgi apparatus
- nucleoplasm
- MLL1 complex
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- protein homodimerization activity