POLA1 Gene Summary [Human]
This gene encodes the catalytic subunit of DNA polymerase, which together with a regulatory and two primase subunits, forms the DNA polymerase alpha complex. The catalytic subunit plays an essential role in the initiation of DNA replication. [provided by RefSeq, Mar 2010]
Details
| Type | Retained Intron |
| Official Symbol | POLA1 |
| Official Name | DNA polymerase alpha 1, catalytic subunit [Source:HGNC Symbol;Acc:HGNC:9173] |
| Ensembl ID | ENSG00000101868 |
| Bio databases IDs | |
| Aliases | DNA polymerase alpha 1, catalytic subunit |
| Synonyms | alpha PRIMASE p180, DNA polymerase alpha, DNA polymerase alpha 1, catalytic subunit, DNA polymerase alpha subunit 1, DNA polymerase α, DNA polymerase α 1, catalytic subunit, DNA polymerase α subunit 1, NSX, p180, PDR, POLA, POLYMERASE alpha, polymerase (DNA directed), alpha 1, polymerase (DNA directed), α 1, POLYMERASE α, VEODS, α PRIMASE p180 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human POLA1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- nucleotide binding
- protein kinase binding
- DNA-directed DNA polymerase
- catalytic domain
- DNA polymerase type-B family
- DNA polymerase (pol2)
- chromatin binding
- enzyme
- protein binding
- pyrimidine nucleotide binding
- purine nucleotide binding
- DNA polymerase family B
- DNA binding
- POLBc
- DNA polymerase family B, exonuclease domain
- zinc ion binding
- DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily
- DNA polymerase alpha subunit p180 N terminal
- double-stranded DNA binding
- DNA Polymerase alpha zinc finger
Pathways
Biological processes and signaling networks where the POLA1 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Hodgkin lymphoma
- refractory multiple myeloma
- neoplasia
- graft-vs-host disease
- plasma cell myeloma
- thalassemia
- liver cancer
- non-promyelocytic acute myeloid leukemia
- relapsed multiple myeloma
- acute myeloid leukemia
regulates
- POLA1
- plasmid
- RNA primer
- primase
- Svl
- DNA polymerase
role in cell
- apoptosis
- cytotoxic reaction
- length
- CCT245737 sensitivity
- repair in
- S phase
- composition
- Robertsonian translocation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- Cytoplasm
- cytosol
- nucleoplasm
- nucleoli
- nuclear envelope
- nuclear matrix
- chromatin
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human POLA1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- DNA repair
- DNA-dependent DNA replication initiation
- lagging strand elongation
- DNA replication
- DNA strand elongation involved in DNA replication
- leading strand elongation
- nucleotide-excision repair
- DNA synthesis involved in DNA repair
- double-strand break repair via nonhomologous end joining
- regulation of type I interferon production
- DNA replication, synthesis of RNA primer
Cellular Component
Where in the cell the gene product is active
- nuclear envelope
- nucleus
- alpha DNA polymerase:primase complex
- cytosol
- nuclear matrix
- nucleolus
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- nucleotide binding
- protein kinase binding
- DNA binding
- DNA replication origin binding
- zinc ion binding
- DNA-directed DNA polymerase activity
- protein binding
- chromatin binding
- single-stranded DNA binding