MAOB Gene Summary
The protein encoded by this gene belongs to the flavin monoamine oxidase family. It is a enzyme located in the mitochondrial outer membrane. It catalyzes the oxidative deamination of biogenic and xenobiotic amines and plays an important role in the metabolism of neuroactive and vasoactive amines in the central nervous sysytem and peripheral tissues. This protein preferentially degrades benzylamine and phenylethylamine. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | MAOB |
| Official Name | monoamine oxidase B [Source:HGNC Symbol;Acc:HGNC:6834] |
| Ensembl ID | ENSG00000069535 |
| Bio databases IDs | |
| Aliases | monoamine oxidase B |
| Synonyms | 6330414K01Rik,monoamine oxidase B |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Rossmann-fold NAD(P)(+)-binding proteins
- mitochondrial presequence
- electron carrier
- flavin adenine dinucleotide binding
- amine oxidase
- enzyme
- protein binding
- identical protein binding
- amine oxidase (flavin-containing)
- NAD(P)-binding Rossmann-like domain
- transmembrane domain
- Flavin containing amine oxidoreductase
- CH-NH2 group:oxygen oxidoreductase
Pathways
Biological processes and signaling networks where the MAOB gene plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Huntington disease
- non-insulin-dependent diabetes mellitus
- obesity
- bipolar depression
- Parkinson disease
- idiopathic Parkinson disease
- apathetic behavior
- major depression
- astrocytosis
- depressive disorder
regulated by
- PF 9601N
- beta-estradiol
- 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine
- ritonavir
- decitabine
- tranylcypromine
- calphostin C
- 2-phenethylamine
- medroxyprogesterone acetate
- rasagiline
regulates
- 5-hydroxytryptamine
- norepinephrine
- 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine
- biogenic monoamine derivative
- 1-methyl-4-phenylpyridinium
- SNCA
- 2-hydroxyphenethylamine
- dopamine
- Mitochondrial ETC 1
- 5-hydroxyindol-3-acetic acid
role in cell
- activation in
- cell death
- activation
- loss
- oxidative stress response
- neurotoxicity in
- conversion in
- oxidative stress response in
- metabolism in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- mitochondrial fraction
- pH resistant lipid raft fraction
- mitochondrial envelope
- Mitochondria
- mitochondrial outer membrane
- perikaryon
- dendrites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the MAOB gene, providing context for its role in the cell.
biological PROCESS
Functions and activities the gene product is involved in
- phenylethylamine catabolic process
- response to aluminum ion
- negative regulation of serotonin secretion
- dopamine catabolic process
- response to xenobiotic stimulus
- response to toxin
- substantia nigra development
- positive regulation of dopamine metabolic process
- response to corticosterone stimulus
- response to ethanol
- response to selenium ion
- response to lipopolysaccharide
- hydrogen peroxide biosynthetic process
cellular COMPONENT
Where in the cell the gene product is active
- dendrite
- mitochondrion
- neuronal cell body
- mitochondrial outer membrane
- mitochondrial envelope
molecular FUNCTION
What the gene product does at the molecular level
- identical protein binding
- protein binding
- aliphatic-amine oxidase activity
- flavin adenine dinucleotide binding
- primary amine oxidase activity
- electron carrier activity