Fstl1 Gene Summary [Mouse]
Predicted to enable calcium ion binding activity and heparin binding activity. Involved in endothelial cell differentiation; endothelial cell migration; and negative regulation of apoptotic process. Acts upstream of or within hematopoietic stem cell homeostasis. Located in extracellular space. Is expressed in several structures, including cardiovascular system; central nervous system; genitourinary system; limb; and sensory organ. Used to study pulmonary emphysema. Orthologous to human FSTL1 (follistatin like 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Fstl1 |
| Official Name | follistatin-like 1 [Source:MGI Symbol;Acc:MGI:102793] |
| Ensembl ID | ENSMUSG00000022816 |
| Bio databases IDs | |
| Aliases | follistatin-like 1 |
| Synonyms | Follistatin-like, follistatin-like 1, FRP, FSL1, FSTL, MIR198, OCC-1, TSC-36 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Fstl1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- EFh_SPARC_EC
- EF-hand domain pair
- EFh
- protein binding
- KAZAL_FS
- heparin binding
- Follistatin/Osteonectin-like EGF domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- androgenic alopecia
- bacterial sepsis
- gastric cancer
- airway hyperresponsiveness
- myocardial infarction
- neoplasia
- hepatic fibrosis
- hepatic steatosis
- age-related macular degeneration
- arthritis
role in cell
- expression in
- production in
- migration
- phosphorylation in
- apoptosis
- differentiation
- activation in
- proliferation
- maturation
- cell death
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Plasma Membrane
- vesicles
- endoplasmic reticulum lumen
- perikaryon
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Fstl1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- multicellular organismal development
- negative regulation of apoptotic process
- cell differentiation
- endothelial cell differentiation
- endothelial cell migration
- regulation of BMP signaling pathway
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum lumen
- extracellular space
- extracellular vesicular exosome
- extracellular region
Molecular Function
What the gene product does at the molecular level
- protein binding
- calcium ion binding
- heparin binding