Il12a Gene Summary [Mouse]
Enables interleukin-12 beta subunit binding activity. Contributes to cytokine activity. Acts upstream of or within several processes, including T-helper 1 cell activation; defense response to protozoan; and positive regulation of T cell activation. Located in cell surface; cytoplasm; and extracellular space. Part of interleukin-12 complex. Is expressed in brain; lung; small intestine; testis; and thymus. Human ortholog(s) of this gene implicated in hepatitis C; hepatocellular carcinoma; and primary biliary cholangitis. Orthologous to human IL12A (interleukin 12A). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Il12a |
| Official Name | interleukin 12a [Source:MGI Symbol;Acc:MGI:96539] |
| Ensembl ID | ENSMUSG00000027776 |
| Bio databases IDs | |
| Aliases | interleukin 12a |
| Synonyms | CLMF, IL-12p35, interleukin 12A, Ll12a, NFSK, NKSF1, P35 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Il12a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- interleukin-12 beta subunit binding
- Interleukin-12 alpha subunit
- interleukin-27 binding
- protein binding
- cytokine
- protein heterodimerization
- growth factor
Pathways
Biological processes and signaling networks where the Il12a gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- Communication between Innate and Adaptive Immune Cells
- Crosstalk between Dendritic Cells and Natural Killer Cells
- Dendritic Cell Maturation
- Differential Regulation of Cytokine Production in Intestinal Epithelial Cells by IL-17A and IL-17F
- Differential Regulation of Cytokine Production in Macrophages and T Helper Cells by IL-17A and IL-17F
- Erythropoietin Signaling
- Hepatic Cholestasis
- HMGB1 Signaling
- IL-12 Signaling and Production in Macrophages
- Role of Cytokines in Mediating Communication between Immune Cells
- Role of Hypercytokinemia/hyperchemokinemia in the Pathogenesis of Influenza
- Role of Pattern Recognition Receptors in Recognition of Bacteria and Viruses
- Serotonin Receptor Signaling
- T Helper Cell Differentiation
- Th1 and Th2 Activation Pathway
- Th1 Pathway
- Th17 Activation Pathway
- Th2 Pathway
- Toll-like Receptor Signaling
- VDR/RXR Activation
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- psoriasis
- cancer
- epithelial cancer
- skin cancer
- epithelial neoplasia
- skin neoplasia
- neoplasia
- encephalomyelitis
- breast adenocarcinoma
- breast carcinoma
role in cell
- expression in
- quantity
- growth
- apoptosis
- activation in
- proliferation
- cellular infiltration by
- production in
- differentiation
- transactivation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Golgi lumen
- Cytoplasm
- cell surface
- endosomes
- endoplasmic reticulum lumen
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Il12a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of smooth muscle cell apoptotic process
- extrinsic apoptotic signaling pathway
- positive regulation of cell adhesion
- positive regulation of tyrosine phosphorylation of STAT protein
- response to virus
- positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target
- positive regulation of mononuclear cell proliferation
- negative regulation of vascular endothelial growth factor signaling pathway
- immune response
- positive regulation of lymphocyte proliferation
- positive regulation of interferon-gamma production
- negative regulation of smooth muscle cell proliferation
- positive regulation of dendritic cell chemotaxis
- negative regulation of interleukin-17 production
- cell migration
- defense response to Gram-positive bacterium
- negative regulation of protein secretion
- positive regulation of natural killer cell mediated cytotoxicity
- positive regulation of NK T cell activation
- positive regulation of natural killer cell activation
- response to lipopolysaccharide
- positive regulation of T cell mediated cytotoxicity
- response to UV-B
- interleukin-12-mediated signaling pathway
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum lumen
- extracellular space
- late endosome lumen
- extracellular region
- interleukin-12 complex
Molecular Function
What the gene product does at the molecular level
- growth factor activity
- protein binding
- protein heterodimerization activity
- interleukin-12 beta subunit binding
- interleukin-12 receptor binding
- cytokine activity
- interleukin-27 binding