Wnt7a

Enables frizzled binding activity. Involved in several processes, including dendritic spine morphogenesis; modulation of chemical synaptic transmission; and reproductive structure development. Acts upstream of or within several processes, including blood vessel morphogenesis; central nervous system development; and embryonic limb morphogenesis. Located in cell surface and extracellular matrix. Is active in Schaffer collateral - CA1 synapse and glutamatergic synapse. Is expressed in several structures, including alimentary system; brain; embryo ectoderm; reproductive system; and sensory organ. Used to study Fuhrmann syndrome. Human ortholog(s) of this gene implicated in Fuhrmann syndrome and Schinzel type phocomelia. Orthologous to human WNT7A (Wnt family member 7A). [provided by Alliance of Genome Resources, Jul 2025]

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Wnt7a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.

Biological processes and signaling networks where the Wnt7a gene in mouse plays a role, providing insight into its function and relevance in health or disease.

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.

Describes the biological processes, cellular components, and molecular functions associated with the mouse Wnt7a gene, providing context for its role in the cell.