Zpbp2 Gene Summary [Mouse]
Acts upstream of or within several processes, including binding activity of sperm to zona pellucida; membrane lipid metabolic process; and regulation of gene expression. Located in acrosomal vesicle and cell body. Part of zona pellucida receptor complex. Is expressed in lung. Orthologous to human ZPBP2 (zona pellucida binding protein 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Zpbp2 |
| Official Name | zona pellucida binding protein 2 [Source:MGI Symbol;Acc:MGI:1916626] |
| Ensembl ID | ENSMUSG00000017195 |
| Bio databases IDs | |
| Aliases | zona pellucida binding protein 2 |
| Synonyms | 1700017D11RIK, 2610022C02RIK, zona pellucida binding protein 2, ZPBPL |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Zpbp2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Nine Cysteines Domain of family 3 GPCR
- Zona-pellucida-binding protein (Sp38)
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- asthma
- atrial fibrillation
- cardiovascular disorder
- allergic rhinitis
- insulin-dependent diabetes mellitus
- rheumatoid arthritis
- autoimmune disease
- systemic sclerosis
- teratozoospermia
regulated by
- tetradecanoylphorbol acetate
- genomic DNA
regulates
- sphingolipid
- phospholipid
- Immunoglobulin
role in cell
- assembly
- binding
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- acrosome
- perikaryon
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Zpbp2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- acrosome assembly
- binding of sperm to zona pellucida
- circadian regulation of gene expression
- negative regulation of immunoglobulin production
- membrane lipid catabolic process
- sphingolipid metabolic process
Cellular Component
Where in the cell the gene product is active
- nucleus
- acrosomal vesicle
- cell body
- extracellular region
- sperm protein complex