Kcnn3 Gene Summary [Rat]
Enables small conductance calcium-activated potassium channel activity. Involved in potassium ion transport. Located in filopodium; neuromuscular junction; and neuronal cell body. Human ortholog(s) of this gene implicated in paranoid schizophrenia and schizophrenia. Orthologous to human KCNN3 (potassium calcium-activated channel subfamily N member 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Kcnn3 |
| Official Name | potassium calcium-activated channel subfamily N member 3 [Source:RGD Symbol;Acc:2964] |
| Ensembl ID | ENSRNOG00000020706 |
| Bio databases IDs | |
| Aliases | potassium calcium-activated channel subfamily N member 3 |
| Synonyms | hSK3, KCa2.3, potassium calcium-activated channel subfamily N member 3, potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3, SK3, SKCA3, ZLS3 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Kcnn3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Calcium-activated SK potassium channel
- inward rectifier potassium channel
- binding protein
- calmodulin binding
- small conductance calcium-activated potassium channel
- calmodulin binding domain
- alpha helix
- protein binding
- ion channel
Pathways
Biological processes and signaling networks where the Kcnn3 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- lung adenocarcinoma
- urothelial cancer
- hepatocellular carcinoma
- liver cancer
- COVID-19
- follicular B-cell or T-cell lymphoma
- Alzheimer disease
- plasma cell myeloma
- hereditary disorder
regulates
- K+
- Ca2+
- Oxphos (complex)
- KCNN2
role in cell
- entrance
- migration
- autophagy in
- autophagy
- action potential
- hyperpolarization
- afterhyperpolarization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- membrane fraction
- Cytoplasm
- cell borders
- cellular membrane
- Endoplasmic Reticulum
- synaptic vesicles
- neuromuscular junctions
- membrane rafts
- filopodia
- perikaryon
- axons
- mossy fibers
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Kcnn3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- potassium ion transmembrane transport
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- neuronal cell body
- neuron projection
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- calmodulin binding
- inward rectifier potassium channel activity
- small conductance calcium-activated potassium channel activity