Neurod2 Gene Summary [Rat]
Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific; E-box binding activity; and protein heterodimerization activity. Predicted to be involved in several processes, including nervous system development; regulation of DNA-templated transcription; and regulation of synapse maturation. Predicted to act upstream of or within associative learning; behavioral fear response; and neuron development. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 72. Orthologous to human NEUROD2 (neuronal differentiation 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Pseudogene |
| Official Symbol | Neurod2 |
| Official Name | neuronal differentiation 2 [Source:RGD Symbol;Acc:3166] |
| Ensembl ID | ENSRNOG00000028417 |
| Bio databases IDs | |
| Aliases | neuronal differentiation 2 |
| Synonyms | bHLHa1, DEE72, EIEE72, NDRF, neurogenic differentiation 2, neuronal differentiation 2 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Neurod2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- transcription regulator
- nucleic acid binding
- basic Helix Loop Helix (bHLH) domain superfamily
- protein binding
- sequence-specific DNA binding
- DNA binding
- Neuronal helix-loop-helix transcription factor
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- double-stranded DNA binding
- helix loop helix domain
- Helix-loop-helix DNA-binding domain
- transcription factor activity
- protein heterodimerization
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- early infantile epileptic encephalopathy type 72
- androgenic alopecia
role in cell
- expression in
- quantity
- differentiation
- loss
- formation
- neurogenesis
- response by
- targeting
- development
- fasciculation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Neurod2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of synapse maturation
- nervous system development
- positive regulation of neuron differentiation
- positive regulation of transcription from RNA polymerase II promoter
- positive regulation of sequence-specific DNA binding transcription factor activity
- associative learning
- cerebellar cortex development
- sensory organ development
- regulation of transcription from RNA polymerase II promoter
- behavioral fear response
- positive regulation of calcium-mediated signaling
- cellular response to calcium ion
- positive regulation of synaptic plasticity
- cellular response to electrical stimulus
- negative regulation of synapse maturation
- protein ubiquitination
Cellular Component
Where in the cell the gene product is active
- nucleus
- chromatin
Molecular Function
What the gene product does at the molecular level
- sequence-specific DNA binding transcription factor activity
- protein heterodimerization activity
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- E-box binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity