Gap43 Gene Summary [Rat]
Enables lysophosphatidic acid binding activity; phosphatidylinositol phosphate binding activity; and phosphatidylserine binding activity. Involved in several processes, including regulation of postsynaptic specialization assembly; response to auditory stimulus; and tissue regeneration. Is active in GABA-ergic synapse and presynapse. Biomarker of middle cerebral artery infarction. Orthologous to human GAP43 (growth associated protein 43). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Gap43 |
| Official Name | growth associated protein 43 [Source:RGD Symbol;Acc:62071] |
| Ensembl ID | ENSRNOG00000001528 |
| Bio databases IDs | |
| Aliases | growth associated protein 43 |
| Synonyms | B-50, Basp2, growth associated protein 43, Neuromodulin, PP46 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Gap43 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- phospholipid binding
- palmitoylation site
- Calmodulin-binding motif
- IQ (isoleucine-glutamine) motif containing G and D (IQCG and IQCD)
- PKC phosphorylation site
- binding protein
- protein binding
- Gap junction protein N-terminal region
- Neuromodulin
- phosphatidylinositol binding
- IQ calmodulin-binding motif
Pathways
Biological processes and signaling networks where the Gap43 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- COVID-19
- schizophrenia
- Alzheimer disease
- seizures
- Parkinson-dementia syndrome
- glioblastoma
- proliferative diabetic retinopathy
- glioblastoma cancer
- Down syndrome
- hemangioma
role in cell
- outgrowth
- quantity
- expression in
- differentiation
- formation
- density
- growth
- proliferation
- elongation
- elongation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- detergent-insoluble membrane fraction
- microsomal fraction
- myelin enriched fraction
- synaptic plasma membrane fractions
- raft fractions
- membrane fraction
- Cytoplasm
- presynaptic regions
- cell surface
- cell periphery
- perinuclear region
- cellular membrane
- Nucleus
- endosomes
- vesicles
- Golgi Apparatus
- sarcomere
- presynaptic membrane
- synaptic membrane
- synaptic vesicles
- growth cone
- neurites
- nerve ending
- synaptosomes
- synapse
- filopodia
- perikaryon
- axons
- postsynaptic density
- presynaptic terminals
- lamellipodia
- cytoskeletal fraction
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Gap43 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of filopodium assembly
- astrocyte differentiation
- cell fate commitment
- response to wounding
- response to auditory stimulus
- radial glial cell differentiation
- axon choice point recognition
- tissue regeneration
- protein kinase C-activating G-protein coupled receptor signaling pathway
- regulation of growth
- axon regeneration
Cellular Component
Where in the cell the gene product is active
- filopodium membrane
- dendrite
- postsynaptic density
- cytoplasm
- growth cone membrane
- perikaryon
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- calmodulin binding
- phosphatidylserine binding
- protein binding
- lysophosphatidic acid binding