ID3
ID3 Gene Summary
The protein encoded by this gene is a helix-loop-helix (HLH) protein that can form heterodimers with other HLH proteins. However, the encoded protein lacks a basic DNA-binding domain and therefore inhibits the DNA binding of any HLH protein with which it interacts. [provided by RefSeq, Aug 2011]
Details
| Type | Protein Coding |
| Official Symbol | ID3 |
| Official Name | inhibitor of DNA binding 3, HLH protein [Source:HGNC Symbol;Acc:HGNC:5362] |
| Ensembl ID | ENSG00000117318 |
| Bio databases IDs | |
| Aliases | inhibitor of DNA binding 3, HLH protein, inhibitor of differentiation 3 |
| Synonyms | bHLHb25,HEIR-1,Helix-loop-helix protein (Id related),HLH 1R21,Hlh462,IDB3,INHIBITOR of DNA binding 3 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- binding protein
- fatty acid binding
- basic Helix Loop Helix (bHLH) domain superfamily
- helix loop helix domain
- transcription factor binding
- protein domain specific binding
- protein binding
- helix-loop-helix domain
- phosphorylation site
Pathways
Biological processes and signaling networks where the ID3 gene plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- CDK2
- TCF3
- BHLH class I
- TCF4
- PAX7
- SMAD3
- CDK1
- HMGA1
- MYOD1
- ZNF408
disease
- Huntington disease
- cancer
- epithelial cancer
- epithelial neoplasia
- lymphomagenesis
- neoplasia
- anxiety disorder
- abdominal cancer
- prostate cancer
- B-cell non-Hodgkin disease
regulated by
- tretinoin
- GH1
- MYC
- cyclosporin A
- hydrogen peroxide
- TGFB1
- Ca2+
- reactive oxygen species
- tetradecanoylphorbol acetate
- TNF
regulates
- TP53
- synthetic promoter
- PPARG
- IFNG
- RAD51
- IL6
- Immunoglobulin
- HIF1A
- DUSP1
- CXCL8
role in cell
- proliferation
- apoptosis
- expression in
- activation in
- phosphorylation in
- binding in
- generation
- activity
- downregulation in
- growth
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the ID3 gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- neuron differentiation
- negative regulation of sequence-specific DNA binding transcription factor activity
- regulation of DNA replication
- odontogenesis
- negative regulation of osteoblast differentiation
- epithelial cell differentiation
- negative regulation of transcription from RNA polymerase II promoter
- muscle organ development
- negative regulation of gene expression
- heart development
- circadian regulation of gene expression
- central nervous system development
- negative regulation of transcription, DNA-dependent
- metanephros development
- notochord development
- negative regulation of myoblast differentiation
- positive regulation of gene expression
- positive regulation of apoptotic process
- cell differentiation
CELLULAR COMPONENT
Where in the cell the gene product is active
- nucleus
- cytoplasm
- nucleoplasm
MOLECULAR FUNCTION
What the gene product does at the molecular level
- protein domain specific binding
- protein binding
- protein dimerization activity
- bHLH transcription factor binding