KRT5
KRT5 Gene Summary
The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in the basal layer of the epidermis with family member KRT14. Mutations in these genes have been associated with a complex of diseases termed epidermolysis bullosa simplex. The type II cytokeratins are clustered in a region of chromosome 12q12-q13. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | KRT5 |
| Official Name | keratin 5 [Source:HGNC Symbol;Acc:HGNC:6442] |
| Ensembl ID | ENSG00000186081 |
| Bio databases IDs | |
| Aliases | keratin 5 |
| Synonyms | 3300001P10Rik,CK5,Cytokeratin5,DDD,DDD1,EBS1,EBS2,EBS2A,EBS2B,EBS2C,EBS2D,EBS2E,EBS2F,K5,Keratin 5,Krt2-5,KRT5A,Sak57,Tfip8 |
| Species | Human, homo_sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- structural constituent of cytoskeleton
- protein binding
- Intermediate filament protein
- Keratin type II head
- head domain
Pathways
Biological processes and signaling networks where the KRT5 gene plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- NR3C1
- KRT18
- KRT17
- ADRB2
- BRCA1
- EFTUD2
- TP53
- UBE2H
- INVS
- HNRNPA1
disease
- cancer
- chronic sinusitis
- psoriasis
- atopic dermatitis
- epithelial cancer
- idiopathic pulmonary fibrosis
- autosomal recessive generalized intermediate epidermolysis bullosa simplex type 2D
- localized epidermolysis bullosa simplex 2C
- autosomal recessive generalized severe epidermolysis bullosa simplex type 2D
- skin neoplasm
regulated by
- TNF
- progesterone
- EGF
- doxorubicin
- glucocorticoid
- beta-estradiol
- ESR1
- IL4
- PRL
- WWTR1
regulates
- MAPK1
- VEGFA
- MAPK3
- ICAM1
- HIF1A
- SERPINF1
- KRT5
role in cell
- transactivation in
- migration
- size
- localization
- polymerization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- detergent resistant lipid raft fraction
- cornified envelope
- Plasma Membrane
- intermediate filaments
- cytosol
- keratin intermediate filaments
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the KRT5 gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- regulation of protein localization
- epidermis development
- regulation of cell migration
- keratinization
- intermediate filament organization
- response to mechanical stimulus
- intermediate filament polymerization
CELLULAR COMPONENT
Where in the cell the gene product is active
- nucleus
- keratin filament
- extracellular vesicular exosome
- cytoplasm
- membrane
- cytosol
- intermediate filament
MOLECULAR FUNCTION
What the gene product does at the molecular level
- scaffold protein binding
- structural constituent of epidermis
- protein binding
- structural constituent of cytoskeleton